公开(公告)号：EP2059517A1

公开(公告)日：2009-05-20

申请号：EP07819987.4

申请日：2007-08-29

申请人： Biovitrum AB (publ)

发明人： BRANDT, Peter ,  JOHANSSON, Gary ,  JOHANSSON, Lars ,  KOOLMEISTER, Tobias ,  NILSSON, Björn M ,  SANDVALL, Teresa ,  WEBER, Michael

IPC分类号： C07D401/12 ,  A61K31/506 ,  A61P3/00 ,  C07D401/14

CPC分类号： A61K31/4545 ,  A61K31/496 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  A61K2300/00

摘要： The present invention relates to compounds of Formula (1a) and pharmaceutically acceptable salts, hydrates, geometrical isomers, racemates, tautomers, optical isomers and N-oxides thereof, wherein W1 and W3 are N and W and W4 are CR12, or W1 and W3 are CR12 and W2 and W4 are N. The invention also relates to pharmaceutical compositions comprising these compounds, and to the use of these compounds for the prophylaxis and treatment of medical conditions relating to disorders of the G-protein-coupled receptor GPR119, such as diabetes and obesity.

公开(公告)号：EP2046741A1

公开(公告)日：2009-04-15

申请号：EP07787013.7

申请日：2007-07-03

申请人： BIOVITRUM AB (publ)

发明人： JOHANSSON, Gary ,  ANGBRANT, Johan ,  RINGOM, Rune ,  HAMMER, Kristin ,  RINGBERG, Erik ,  LINDQVIST, Bengt ,  BRANDT, Peter ,  BEIERLEIN, Katarina ,  NILSSON, Björn, M.

IPC分类号： C07D209/14

CPC分类号： C07D401/06 ,  C07D209/08 ,  C07D401/12 ,  C07D403/06 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

摘要： The present invention relates to novel compounds of formula (I) wherein m, n, R0, R1, R2, R3 and R4 are as described herein, to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds for the preparation of a medicament against 5-HT6 receptor-related disorders.

公开(公告)号：EP1896460A1

公开(公告)日：2008-03-12

申请号：EP06763743.9

申请日：2006-06-15

申请人： Biovitrum AB (publ)

发明人： CALDIROLA, Patrizia ,  JOHANSSON, Gary ,  SUTIN, Lori

IPC分类号： C07D405/12 ,  A61K31/443 ,  A61P3/04

CPC分类号： C07D405/12

摘要： The present invention relates to compounds of the formula (I), wherein R1 and R2 are as defined in the description; to pharmaceutical formulations comprising these compounds, and to the use of the compounds for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes, and/or CNS disorders, to achieve reduction of body weight and of body weight gain.

摘要翻译： 本发明涉及式（I）的化合物，其中R 1和R 2如说明书中所定义; 涉及包含这些化合物的药物制剂，以及涉及这些化合物用于预防和治疗与肥胖症，II型糖尿病和/或CNS疾病有关的医学病症的用途，以实现体重和体重增加的降低。

公开(公告)号：EP1896460B1

公开(公告)日：2009-07-22

申请号：EP06763743.9

申请日：2006-06-15

申请人： Biovitrum AB (publ)

发明人： CALDIROLA, Patrizia ,  JOHANSSON, Gary ,  SUTIN, Lori

IPC分类号： C07D405/12 ,  A61K31/443 ,  A61P3/04

CPC分类号： C07D405/12

摘要： The present invention relates to compounds of the formula (I), wherein R1 and R2 are as defined in the description; to pharmaceutical formulations comprising these compounds, and to the use of the compounds for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes, and/or CNS disorders, to achieve reduction of body weight and of body weight gain.

公开(公告)号：EP2059516A1

公开(公告)日：2009-05-20

申请号：EP07803008.7

申请日：2007-08-29

申请人： BIOVITRUM AB (publ)

发明人： BRANDT, Peter ,  EMOND, Rikard ,  JOHANSSON, Gary ,  JOHANSSON, Lars ,  KOOLMEISTER, Tobias ,  NILSSON, Björn, M. ,  SANDVALL, Teresa ,  WEBER, Michael

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/4545 ,  A61K31/496 ,  A61P3/00

CPC分类号： A61K31/4545 ,  A61K31/496 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  A61K2300/00

摘要： The present invention relates to compounds of Formula (Ia) and pharmaceutically acceptable salts, hydrates, geometrical isomers, racemates, tautomers, optical isomers and N-oxides thereof, wherein one of W1 and W2 is N and the other is CR12. The invention also relates to pharmaceutical compositions comprising these compounds, and to the use of these compounds for the prophylaxis and treatment of medical conditions relating to disorders of the G-protein-coupled receptor GPRl 19, such as diabetes and obesity.