公开(公告)号：EP2044051B1

公开(公告)日：2010-01-27

申请号：EP07786791.9

申请日：2007-06-21

申请人： BIOVITRUM AB (publ)

发明人： JENMALM JENSEN, Annika ,  RINGOM, Rune ,  MEDINA, Carmen ,  SHILVOCK, John ,  WIIK, Marie ,  KOOLMEISTER, Tobias ,  ANGBRANT, Johan ,  SUTIN, Lori ,  HENRIKSSON, Martin ,  SANDVALL, Teresa ,  JOHANSSON, Lars ,  NILSSON, Björn

IPC分类号： C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D471/04

CPC分类号： C07D401/12 ,  C07D401/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D471/04

摘要： The present invention relates to compounds of the general formula (I) wherein X, Y, Z, A, Ar, R1, R2, R3, and R4 are as defined herein, which compounds are inhibitors of MNK2 and MNK1. The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds, and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of disorders related to undesired activity of MNK1 and/or MNK2 kinases.

公开(公告)号：EP2091953A1

公开(公告)日：2009-08-26

申请号：EP07835158.2

申请日：2007-10-30

申请人： BIOVITRUM AB (publ)

发明人： BERTS, Wei ,  BRANDT, Peter ,  HAMMER, Kristin ,  HENRIKSSON, Sofia ,  LINDQVIST, Bengt ,  RINGBERG, Erik ,  RINGOM, Rune

IPC分类号： C07D498/04 ,  C07D498/18 ,  A61K31/553

CPC分类号： C07D498/04 ,  C07D498/18

摘要： The present invention relates to compounds of the formula (I) wherein A, X and R1 to R9 are as described herein; to pharmaceutical compositions comprising the said compounds; to processes for their preparation; and to the use of the compounds as medicaments against 5-HT6 receptor-related disorders.

公开(公告)号：EP2046741A1

公开(公告)日：2009-04-15

申请号：EP07787013.7

申请日：2007-07-03

申请人： BIOVITRUM AB (publ)

发明人： JOHANSSON, Gary ,  ANGBRANT, Johan ,  RINGOM, Rune ,  HAMMER, Kristin ,  RINGBERG, Erik ,  LINDQVIST, Bengt ,  BRANDT, Peter ,  BEIERLEIN, Katarina ,  NILSSON, Björn, M.

IPC分类号： C07D209/14

CPC分类号： C07D401/06 ,  C07D209/08 ,  C07D401/12 ,  C07D403/06 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

摘要： The present invention relates to novel compounds of formula (I) wherein m, n, R0, R1, R2, R3 and R4 are as described herein, to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds for the preparation of a medicament against 5-HT6 receptor-related disorders.

公开(公告)号：EP2134714A1

公开(公告)日：2009-12-23

申请号：EP08717746.5

申请日：2008-03-13

申请人： Biovitrum AB (publ)

发明人： ANGBRANT, Johan ,  BRANDT, Peter ,  RINGOM, Rune ,  LINDQVIST, Bengt

IPC分类号： C07D471/06 ,  C07D487/06 ,  A61K31/4745 ,  A61P3/04

CPC分类号： C07D471/06 ,  C07D487/06

摘要： The present invention relates to novel compounds of formula (I): wherein R1, R2, R3, R4, and R5 are as described herein, to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds for the preparation of a medicament against 5-HT6 receptor-related disorders.

公开(公告)号：EP2044051A1

公开(公告)日：2009-04-08

申请号：EP07786791.9

申请日：2007-06-21

申请人： BIOVITRUM AB (publ)

发明人： JENMALM JENSEN, Annika ,  RINGOM, Rune ,  MEDINA, Carmen ,  SHILVOCK, John ,  WIIK, Marie ,  KOOLMEISTER, Tobias ,  ANGBRANT, Johan ,  SUTIN, Lori ,  HENRIKSSON, Martin ,  SANDVALL, Teresa ,  JOHANSSON, Lars ,  NILSSON, Björn

IPC分类号： C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D471/04

CPC分类号： C07D401/12 ,  C07D401/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D471/04

摘要： The present invention relates to compounds of the general formula (I) wherein X, Y, Z, A, Ar, R1, R2, R3, and R4 are as defined herein, which compounds are inhibitors of MNK2 and MNK1. The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds, and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of disorders related to undesired activity of MNK1 and/or MNK2 kinases.