公开(公告)号：EP0589487A1

公开(公告)日：1994-03-30

申请号：EP93116126.9

申请日：1990-03-14

申请人： BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA ,  BIONEBRASKA, INC.

发明人： Wagner, Fred W. ,  Wylie, Dwane E. ,  Schuster, Sheldon M. ,  Coolidge, Thomas R. ,  Song, Pill-Soon ,  Parker, William

IPC分类号： C12P21/08 ,  C12N5/16 ,  G01N33/53 ,  G01N33/84 ,  C07K15/28

CPC分类号： C07K16/44 ,  C07K2317/55 ,  G01N33/5308 ,  G01N33/54353 ,  G01N33/68 ,  G01N33/84

摘要： The present invention is directed to monoclonal antibodies and fragments thereof for immunoreaction with organic compounds having a molecular size of no more than about 15 atoms in length and being a linear or branched aliphatic molecule or a small peptide. The invention is as well directed to hybridomas which produce the monoclonal antibodies, to immunogen compounds of the organic compound which cause development of the appropriate mammalian antibody response and to methods for producing antibody fragments. The invention is further directed to methods for detecting, removing, adding or neutralizing the organic compounds in biological and inanimate systems through the use of the monoclonal antibodies or fragments thereof.

摘要翻译： 本发明涉及用于与分子大小不超过约15个原子长度并且是直链或支链脂族分子或小肽的有机化合物进行免疫反应的单克隆抗体及其片段。 本发明还针对产生单克隆抗体的杂交瘤，引起合适的哺乳动物抗体应答发展的有机化合物的免疫原化合物和产生抗体片段的方法。 本发明还涉及通过使用单克隆抗体或其片段来检测，除去，添加或中和生物和无生物体系中的有机化合物的方法。