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公开(公告)号：EP2087359A1
公开(公告)日：2009-08-12
申请号：EP07818642.6
申请日：2007-10-02
发明人： GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT-KÜPPER, Barbara , KLEIN, Martina , STEPPAN, Sonja , ELLINGHAUS, Peter , D'URSO, Donatella , SEEWALD, Michael , MILTING, Hendrik
CPC分类号： G01N33/573 , C12Q1/37 , G01N2333/948
摘要： The invention provides PRSS23 which is associated with the cardiovascular diseases, hematological diseases, neurological diseases, respiratory diseases, gastroenterological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, respiratory diseases, gastroenterological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PRSS23 as well as pharmaceutical compositions comprising such compounds. The invention also provides PRSS23 as a biomarker for diseases as cardiovascular diseases, hematological diseases, neurological diseases, respiratory diseases, gastroenterological diseases and urological diseases.
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公开(公告)号：EP2074429A1
公开(公告)日：2009-07-01
申请号：EP07818669.9
申请日：2007-10-04
发明人： GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT-KÜPPER, Barbara , KLEIN, Martina , STEPPAN, Sonja , ELLINGHAUS, Peter , D'URSO, Donatella , SEEWALD, Michael , MILTING, Hendrik
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2800/06 , G01N2800/12 , G01N2800/22 , G01N2800/28 , G01N2800/32 , G01N2800/34
摘要： The invention provides CTGF which is associated with the cardiovascular diseases and hematological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases and hematological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CTGF as well as pharmaceutical compositions comprising such compounds. The invention also provides CTGF as a biomarker for diseases as cardiovascular diseases and hematological diseases
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