公开(公告)号：EP4399324A1

公开(公告)日：2024-07-17

申请号：EP22868335.5

申请日：2022-09-09

Applicant: The Broad Institute, Inc.

Inventor： MACDONALD, Bryan ,  ARDUINI, Alessandro ,  ELOWE, Nadine

IPC: C12Q1/37 ,  G01N33/96 ,  C12N9/50 ,  C12N9/64 ,  A61P9/00 ,  A61K31/00

CPC classification number: A61P9/00 ,  C12Q1/37 ,  C12Y304/24 ,  C12N9/6416 ,  C07K14/473 ,  A61K31/4439 ,  A61K31/4178

公开(公告)号：EP4368724A1

公开(公告)日：2024-05-15

申请号：EP22206451.1

申请日：2022-11-09

Applicant: Universität Regensburg ,  PHILIPPS-UNIVERSITÄT MARBURG

Inventor： The designation of the inventor has not yet been filed

IPC: C12Q1/37

CPC classification number: C12Q1/37

Abstract: The present invention relates to a method of determining complement activity, wherein said method comprises determining classical complement pathway activity, determining alternative complement pathway activity, and/or determining lectin complement pathway activity. The present invention further relates to a liposome collection for determining complement activity. Furthermore, the present invention relates to a kit for determining complement activity. The present invention also relates to a liposome collection or kit for use in a method of diagnosing, monitoring, or treating a complement associated disorder.

公开(公告)号：EP4362966A1

公开(公告)日：2024-05-08

申请号：EP22834245.7

申请日：2022-06-30

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： CRAIK, Charles S. ,  BARDINE, Conner ,  EVANS, Michael

IPC: A61K38/16 ,  A61K47/65

CPC classification number: A61K51/088 ,  A61P35/00 ,  A61P11/00 ,  A61P29/00 ,  G01N2333/9643620130101 ,  C12Q1/37 ,  G01N33/5047 ,  C07K14/001 ,  C07K14/463 ,  C07K2319/0020130101

公开(公告)号：EP4352076A1

公开(公告)日：2024-04-17

申请号：EP22734344.9

申请日：2022-06-13

Applicant: The University Court Of The University of Edinburgh

Inventor： VENDRELL, Marc ,  SCOTT, Jamie I. ,  GORDON, Doireann

IPC: C07K7/06 ,  C12Q1/37

CPC classification number: C07K7/06 ,  C12Q1/37 ,  G01N2800/5220130101

公开(公告)号：EP3060915B1

公开(公告)日：2018-12-05

申请号：EP14790689.5

申请日：2014-10-23

Applicant: Mologic Limited

Inventor： DAVIS, Paul ,  PAREKH, Gita ,  SCHOUTEN, James

IPC: G01N33/543 ,  C12Q1/37 ,  G01N33/573

CPC classification number: G01N33/54386 ,  C12Q1/37 ,  G01N33/558 ,  G01N2333/96486 ,  G01N2800/12 ,  G01N2800/382

Abstract: The present invention relates to detecting cleavage activity of an enzyme. The various aspects of the invention include an enzyme detection device, kit, method and use for detecting or measuring the presence in a test sample of the activity of an enzyme capable of cleaving a substrate. The invention also relates to indicator and binding molecules useful for carrying out the invention. The enzyme substrate contains a hidden binding site which is only revealed upon cleavage by the enzyme.

公开(公告)号：EP3403673A1

公开(公告)日：2018-11-21

申请号：EP17738422.9

申请日：2017-01-11

Applicant: National University Corporation Tokyo Medical and Dental University

Inventor： NISHIMURA, Emi ,  MATSUMURA, Hiroyuki

IPC: A61K45/00 ,  A61K8/97 ,  A61K31/222 ,  A61K31/506 ,  A61K31/7088 ,  A61K31/713 ,  A61K36/04 ,  A61K36/05 ,  A61K36/14 ,  A61K36/18 ,  A61K36/185 ,  A61K36/23 ,  A61K36/28 ,  A61K36/30 ,  A61K36/424 ,  A61K36/47 ,  A61K36/48 ,  A61K36/488 ,  A61K36/489 ,  A61K36/53

CPC classification number: A61K31/713 ,  A61K8/97 ,  A61K31/05 ,  A61K31/16 ,  A61K31/222 ,  A61K31/355 ,  A61K31/375 ,  A61K31/381 ,  A61K31/506 ,  A61K31/7048 ,  A61K31/7088 ,  A61K36/04 ,  A61K36/05 ,  A61K36/14 ,  A61K36/18 ,  A61K36/185 ,  A61K36/23 ,  A61K36/28 ,  A61K36/30 ,  A61K36/424 ,  A61K36/47 ,  A61K36/48 ,  A61K36/488 ,  A61K36/489 ,  A61K36/53 ,  A61K36/54 ,  A61K36/60 ,  A61K36/718 ,  A61K36/738 ,  A61K36/74 ,  A61K36/82 ,  A61K38/55 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P17/14 ,  A61Q5/00 ,  A61Q7/00 ,  C12Q1/37

Abstract: The present invention provides novel compositions for suppressing or improving hair loss, and compositions for suppressing or improving graying. More specifically, it provides agents that stabilize type XVII collagen expression, preferably agents that suppress the degradation of type XVII collagen by ELANE inhibitors and such, and compositions comprising a DNA repair-promoting agent or a DNA damage-suppressing agent as an active ingredient. Advantageous suppressive effects of hair loss and graying can be obtained when a composition comprising as an active ingredient a suppressive agent of type XVII collagen degradation such as an ELANE inhibitor is administered to a mammal. For the ELANE inhibitors, suppressive agents of type XVII collagen degradation and DNA repair-promoting agents, low-molecular compounds, polypeptides, proteins, antibodies, or nucleic acid medicine such as antisense oligos or siRNAs may be used. A method of screening for effective substances for suppression of hair loss and graying is also provided.

公开(公告)号：EP3402385A1

公开(公告)日：2018-11-21

申请号：EP17738245.4

申请日：2017-01-13

Applicant: DiagnosTear, Ltd.

Inventor： SOMMERA, Amos ,  FAKTOR, Ouriel ,  EILAT, Eran

IPC: A61B3/02 ,  C12Q1/06 ,  C12Q1/37 ,  G01N21/64 ,  G01N21/77 ,  G01N33/52 ,  G01N33/558 ,  G01N33/577 ,  G01N33/68

CPC classification number: G01N21/8483 ,  C12Q1/06 ,  C12Q1/37 ,  G01N21/78 ,  G01N33/52 ,  G01N33/558 ,  G01N33/577 ,  G01N33/68 ,  G01N33/6893

Abstract: In one embodiment, the present invention is a method for diagnosing Dry Eye Syndrome by quantifying an amount of at least two markers in a tear sample collected from a subject, wherein the at least two markers are selected from the group consisting of: Human Serum Albumin (HSA), mucin, lactoferrin, and lysozyme. In some embodiments, the method is a multi-assay test.

公开(公告)号：EP3346013A1

公开(公告)日：2018-07-11

申请号：EP16841985.1

申请日：2016-09-01

Applicant: Ultizyme International Ltd.

Inventor： UEDA, Yuki ,  SODE, Koji ,  TSUGAWA, Wakako ,  KURITA, Masaaki ,  NISHIMORI, Takashi

IPC: C12Q1/26 ,  C12M1/34 ,  C12Q1/37 ,  G01N27/30 ,  G01N27/416

CPC classification number: G01N33/49 ,  C12M1/34 ,  C12Q1/26 ,  C12Q1/37 ,  C12Y105/03 ,  G01N27/30 ,  G01N27/416 ,  G01N2440/38 ,  G01N2800/042

Abstract: A method for measuring a glycated protein in a sample, the method comprising (1) a step of allowing a sample in which a degradation product has been generated from a glycated protein by a protease to react with an oxidoreductase in the presence of an electron mediator to generate a reduced electron mediator; and (2) a step of detecting the reaction state in the step (1) by an electrochemical technique using an interdigitated electrode.

公开(公告)号：EP2811031B1

公开(公告)日：2018-07-11

申请号：EP12821102.6

申请日：2012-12-27

Applicant: Centro de Investigación y Desarrollo de Medicamentos (CIDEM) ,  Universidad de La Habana

Inventor： PERDOMO MORALES, Rolando ,  MONTERO ALEJO, Vivian ,  PERERA BRAVET, Erick ,  CALERO CARBONELL, Jorge Ernesto ,  PARDO RUIZ, Zenia ,  PORTO VERDECIA, Marlene ,  VEGA HURTADO, Yamile

IPC: C12Q1/04 ,  C12Q1/26 ,  C12Q1/37

CPC classification number: C12Q1/26 ,  C12Q1/04 ,  C12Q1/37

Abstract: The present invention relates to the pharmaceutics, biotechnological and chemical, and particularly to a process for preparing a composition for detecting and measuring the concentration of endotoxins or lipopolysaccharides, peptidoglycans and (1,3)-²-D-glucans, using an extract from the hemocytes of the lobster as a starting material, the changes to the composition to increase the sensitivity, and processes for measuring endotoxins, peptidoglycans and (1,3)-²-D-glucans using said composition.

公开(公告)号：EP2364326B1

公开(公告)日：2018-07-04

申请号：EP09764259.9

申请日：2009-12-04

Applicant: Glaxo Group Limited

Inventor： ENEVER, Carolyn ,  JESPERS, Laurent ,  PUPECKA, Malgorzata ,  TOMLINSON, Ian M

IPC: G01N33/68 ,  C12Q1/37 ,  C40B40/10

CPC classification number: G01N33/6857 ,  C12Q1/37 ,  C40B40/10 ,  G01N33/6845 ,  G01N2500/02

Abstract: The disclosure relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides (e.g., a display system) that is resistant to degradation by a protease such as a protease found in the serum. Generally, the method comprises providing a library or repertoire of peptides or polypeptides, incubating the library or repertoire with a protease under conditions suitable for protease activity, and selecting, isolating and/or recovering a peptide or polypeptide that is resistant to degradation by the protease and has a desired biological activity. The selected peptides and polypeptides have utility as therapeutics, e.g., for treating disease in humans.