公开(公告)号：EP0489108B1

公开(公告)日：1996-03-13

申请号：EP90913638.4

申请日：1990-08-15

申请人： Beth Israel Hospital Association

发明人： SHARPE, Richard, J. ,  ARNDT, Kenneth, A. ,  GALLI, Stephen, J.

IPC分类号： A61K31/445 ,  A61K31/475

CPC分类号： A61K45/06 ,  A61K8/492 ,  A61K31/00 ,  A61K31/415 ,  A61K31/475 ,  A61Q7/00

摘要： A method and composition for the topical treatment of cutaneous, mucosal or ocular hypersensitivity reactions, inflammation, or epithelial hyperproliferative states, including those associated with scarring. The composition, to be applied directly to an affected area of the skin, eye, or mucosal membrane, consists of a therapeutic amount of reserpine, spiperone, or other serotonin antagonist which has been incorporated into a vehicle suitable for topical administration.

公开(公告)号：EP0520032B1

公开(公告)日：1998-09-16

申请号：EP91907118.3

申请日：1991-03-13

申请人： Beth Israel Hospital Association

发明人： SHARPE, Richard, J. ,  ARNDT, Kenneth, A. ,  GALLI, Stephen, J.

IPC分类号： A61K31/445

CPC分类号： A61K31/445 ,  A61K31/415 ,  A61K31/435 ,  Y10S514/885

摘要： A method for suppressing an immune response or of treating inflammation in a mammal by treating the mammal with an effective amount of spiperone; and a composition including CNS-blind spiperone.