公开(公告)号：EP1414948B1

公开(公告)日：2009-09-16

申请号：EP02742400.1

申请日：2002-07-10

申请人： Biogen Idec Inc. ,  JOHNS HOPKINS UNIVERSITY

发明人： REFF, Mitchell ,  BETENBAUGH, Michael, J. ,  FIGUEROA, Bruno, Jr. ,  AILOR, Eric ,  HARDWICK, Marie

IPC分类号： C12N5/10 ,  C12N5/06 ,  C12N5/08 ,  C12P21/00 ,  C07H21/00 ,  C07K14/00

CPC分类号： C07K14/4747 ,  A61K39/00 ,  A61K48/005 ,  C07K14/721 ,  C07K16/2875 ,  C07K2319/00 ,  C12N15/67 ,  C12N15/85 ,  C12N2800/108 ,  C12N2830/002 ,  C12N2830/15 ,  C12N2840/20 ,  C12N2840/44

摘要： The present invention relates to preventing or delaying programmed cell death by expressing one or more anti-apoptotic polypeptides in a cell such that programmed cell death in the cell is prevented or delayed. The present invention also relates to increasing production of a cell-related product by expressing one or more anti-apoptotic polypeptides in a cell such that production of the cell-related product by the cell is increased. Recombinant cells useful for producing cell-related product or cellular therapy are also provided.