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1.发明公开Improved antibodies having altered effector function and methods for making the same 有权改进的具有改变的效应功能的抗体，以及它们的制备方法
公开(公告)号：EP2502935A3
公开(公告)日：2013-11-13
申请号：EP11195651.2
申请日：2004-08-23
申请人： Biogen Idec MA Inc.
IPC分类号： C07K16/00 , A61K39/395 , C12Q1/37 , C12N1/20 , C12N15/00
CPC分类号： C07K16/2875 , A61K47/60 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/71
摘要： The invention provides a method of producing aglycosylated Fc-containing polypeptides, such as antibodies, having desired effector function. The invention also provides aglycosylated antibodies produced according to the method as well as methods of using such antibodies as therapeutics.
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2.发明公开Improved antibodies having altered effector function and methods for making the same 有权改进的具有改变的效应功能的抗体，以及它们的制备方法
公开(公告)号：EP2502935A2
公开(公告)日：2012-09-26
申请号：EP11195651.2
申请日：2004-08-23
申请人： Biogen Idec MA Inc.
CPC分类号： C07K16/2875 , A61K47/60 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/71
摘要： The invention provides a method of producing aglycosylated Fc-containing polypeptides, such as antibodies, having desired effector function. The invention also provides aglycosylated antibodies produced according to the method as well as methods of using such antibodies as therapeutics.
摘要翻译： 本发明提供的制造方法非糖基化的含Fc的多肽：如抗体，具有所需的效应子功能。 因此本发明提供了雅丁的方法，以及使用抗体作为治疗剂的搜寻方法产生无糖基化的抗体。
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3.发明公开Receptor coupling agents and therapeutic uses thereof 审中-公开Rezeptor-Kupplungsmittel und ihre therapeutischen Verwendungen
公开(公告)号：EP2332992A1
公开(公告)日：2011-06-15
申请号：EP10186088.0
申请日：2005-03-23
申请人： Biogen Idec MA Inc.
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/31 , C07K2317/73 , C07K2317/75 , C07K2319/00 , G01N33/6863 , G01N2333/70575
摘要： Receptor coupling agents, including multivalent constructs comprising anti-TNF receptor binding moieties, for treating cancer and inhibiting tumor volume in a subject are disclosed.
摘要翻译： 公开了受体偶联剂，包括包含抗TNF受体结合部分的多价构建体，用于治疗受试者的癌症和抑制肿瘤体积。
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