公开(公告)号：EP4426327A2

公开(公告)日：2024-09-11

申请号：EP22890796.0

申请日：2022-11-03

Applicant: Apellis Pharmaceuticals, Inc.

Inventor： FRANCOIS, Cedric ,  DESCHATELETS, Pascal ,  GROSSI, Federico

IPC: A61K38/12 ,  A61K47/60 ,  A61P7/06 ,  C07K7/64 ,  C07K14/47

CPC classification number: A61K47/60 ,  A61P29/00 ,  A61K38/12

公开(公告)号：EP4154900B1

公开(公告)日：2024-08-28

申请号：EP22193946.5

申请日：2010-07-29

IPC: A61K38/08 ,  C07K7/06 ,  A61P3/14 ,  A61P5/20 ,  A61P5/00

CPC classification number: A61K38/00 ,  C07K5/1013 ,  A61K47/60 ,  C07K7/06 ,  C07K7/08 ,  A61K9/0019 ,  A61K9/08 ,  A61P13/12 ,  A61P3/00 ,  A61P3/14 ,  A61P43/00 ,  A61P5/00 ,  A61P5/14 ,  A61P5/18 ,  A61P5/20

公开(公告)号：EP3186371B1

公开(公告)日：2024-08-14

申请号：EP15834988.6

申请日：2015-08-28

IPC: C12N9/14 ,  A61K35/14 ,  A61K38/46 ,  A61K39/395 ,  A61K38/00 ,  C07K16/28 ,  C12N9/96 ,  A61K47/60 ,  A61K35/17

CPC classification number: A61K39/3955 ,  C07K16/2818 ,  C07K16/2827 ,  C07K2319/0120130101 ,  A61K38/00 ,  A61K35/17 ,  C12N9/14 ,  C12N9/96 ,  C07K16/2896 ,  C07K16/2887 ,  C12Y307/01003 ,  C07K2317/62220130101 ,  A61K47/60 ,  A61P35/00 ,  A61P43/00

公开(公告)号：EP4404951A1

公开(公告)日：2024-07-31

申请号：EP22793530.1

申请日：2022-09-21

Applicant: Ascendis Pharma Bone Diseases A/S

Inventor： SPROGØE, Kennett

IPC: A61K38/29 ,  A61P5/18 ,  A61K47/60

CPC classification number: A61K38/29 ,  A61K47/60 ,  A61P5/18

公开(公告)号：EP4395748A1

公开(公告)日：2024-07-10

申请号：EP22773178.3

申请日：2022-09-02

Applicant: CureVac SE

Inventor： BAUMHOF, Patrick ,  NAVARRO, Gemma ,  BOLLHORST, Tobias ,  PALMERSTON MENDES, Livia ,  THIELE-SÜSS, Carolin

IPC: A61K9/51 ,  A61K47/60 ,  A61K47/69 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00

CPC classification number: A61K47/60 ,  A61K47/6935

公开(公告)号：EP2964224B1

公开(公告)日：2024-07-03

申请号：EP14760322.9

申请日：2014-03-07

IPC: A61K31/4192 ,  A61K31/5575 ,  A61K31/175 ,  A61P27/06 ,  A61K9/00 ,  A61K31/5377 ,  A61K47/56 ,  A61K47/59 ,  A61K47/60

CPC classification number: A61K9/0051 ,  A61K47/60 ,  A61K47/58 ,  A61K47/59 ,  A61K31/5377 ,  A61K31/5575 ,  A61P27/06

公开(公告)号：EP4389145A2

公开(公告)日：2024-06-26

申请号：EP23217647.9

申请日：2019-09-11

Applicant: Ambrx, Inc.

Inventor： CHEN, Sigeng ,  LU, Yingchun ,  RASHID, Md, Harunur ,  KNUDSEN, Nickolas ,  TIAN, Feng

IPC: A61K45/00

CPC classification number: A61K38/00 ,  C07K14/55 ,  A61K47/60

Abstract: The present invention provides methods for targeting interleukin-2 receptor-expressing cells, and,in particular, inhibiting the growth of such cells by using an interleukin-2 (IL-2) variant conjugated to a biologically active molecule that will affect cells expressing the interleukin-2 receptor.

公开(公告)号：EP3689942B1

公开(公告)日：2024-06-19

申请号：EP18860767.5

申请日：2018-10-01

IPC: C08G65/325 ,  C07K14/62 ,  A61K47/54 ,  A61K47/60 ,  A61K47/68

CPC classification number: C07K14/62 ,  C08G65/325 ,  A61K47/542 ,  A61K47/60 ,  A61K47/68

公开(公告)号：EP4378926A1

公开(公告)日：2024-06-05

申请号：EP21951293.6

申请日：2021-07-29

Applicant: Novocodex Biopharmaceuticals Co., Ltd.

Inventor： YANG, Jinwei ,  YE, Chenghao ,  XIA, Gang ,  HUO, Pengchao ,  DING, Wen ,  CHEN, Longfei ,  JIAO, Lin ,  HUANG, Hao ,  HENG, Xin ,  ZHU, Jingjing ,  YING, Yuebin ,  LIANG, Xuejun

IPC: C07C271/22 ,  C07C235/78 ,  C07C237/12 ,  C07C235/20 ,  C07K14/61 ,  A61K47/54 ,  A61K47/60 ,  A61K38/27 ,  A61P5/06

CPC classification number: A61K38/27 ,  A61K47/54 ,  A61K47/60 ,  A61P5/06 ,  C07C235/20 ,  C07C235/78 ,  C07C237/12 ,  C07C271/22 ,  C07K14/61

Abstract: The invention provides an unnatural amino acid, which is a compound with a structure as shown in formula (I) or an enantiomer thereof. The invention further provides use of the unnatural amino acid. Furthermore, the invention further provides a recombinant protein containing the unnatural amino acid and a protein conjugate prepared from the recombinant protein. The unnatural amino acid provided by the invention is simple and convenient to prepare, safe in nature, not easy to be inactivated when being inserted into a protein, and has a high binding rate with a coupling moiety, and the obtained conjugate is higher in stability. The unnatural amino acid provided by the invention is applicable to numerous fields, especially in preparation of a recombinant protein or a recombinant protein conjugate,

公开(公告)号：EP3697407B1

公开(公告)日：2024-05-29

申请号：EP18867524.3

申请日：2018-10-16

IPC: A61K47/60 ,  A61K31/225 ,  C07C69/60 ,  A61K9/00 ,  A61P17/06 ,  A61P25/00

CPC classification number: A61K31/21 ,  C07C69/60 ,  A61K9/0019 ,  A61K47/34 ,  A61P17/06 ,  A61P25/00 ,  A61K47/60