摘要:
The application provides devices that can be used to deliver a therapeutic agent to a treatment site within the vessel of a patient at increased pressure, while limiting the contact with and pressure placed on the vessel walls. Devices according to the application include an expandable structure (100) arranged around and on a tube (130) having a lumen (140). The expandable structure may include a sealing ring (111) that makes contact with the interior surface of a vessel to prevent or decrease fluid flow during delivery of a therapeutic agent. This allows delivery of a therapeutic agent with decreased risk of injury to the treatment site. The application also provides for large lumen diameters, preventing shearing stress on therapeutic agents such as cell slurries.
摘要:
Needles (10, 200, 300, 400, 500, 600) configured to prevent or reduce contact of tissue or other material with the heel (80) of the needle to prevent coring of the tissue or other material by the heel of the needle. Also provided are needles having no heels or blunted heels. The prevent invention also provides methods of manufacturing needles having obstructed or blunted heels.
摘要:
An apparatus for the injection of therapeutic and other agents at a target site within a patient's body. A catheter including a first elongated shaft having a distal end and a proximal end and a lumen extending therebetween. The catheter also including a second elongated shaft slidingly disposed in the first elongated shaft, the second elongated shaft having a distal end and a proximal and a lumen extending therebetween. The catheter further including a third elongated shaft disposed in and attached to the second elongate shaft, the third elongated shaft to move in a one-to-one relationship with the first elongated shaft and the second elongated shaft to maintain a predetermined needle deployment length as each are subjected to various bend configurations.