摘要:
The present invention generally relates to a medical device for delivering a therapeutic agent to an internal portion of a patient's body. The medical device includes a shaft and a self-expanding delivery member in operative communication with the shaft. The delivery member is shaped from a porous material that is capable of releasing a therapeutic agent to an internal portion of a patient's body. The medical device further includes a therapeutic agent delivery lumen in fluid communication with the delivery member to fluidly connect the delivery member with a therapeutic agent source. A retention member may also be provided to selectively collapse the delivery member.
摘要:
A balloon catheter having a first balloon member and a second distal expandable member. The increased distal profile of the catheter with inflation of the second distal expandable member can deflect the distal-most end away from stent walls and edges. Another catheter has a distal region including longitudinal slits and a pre-stressed body configured to expand upon exposure to warm body fluids. Another catheter has a distal region including a first, inner tube disposed about a second, innermost tube. The inner and innermost tubes are secured at the distal-most end. The distal region includes longitudinal slits through the inner tube, thereby defining flaps between the slits. The innermost tube can be retracted relative to the inner tube disposed about the innermost tube, thereby causing the longitudinal flaps to expand outward, thereby increasing the maximum radial extent of the distal region. In yet another embodiment, a balloon catheter having a first guide wire tube is provided. A second guide wire tube is also provided, adapted to be received within the larger, first guide wire tube.
摘要:
A catheter adapted to deliver therapeutic or diagnostic agents to a target tissue of a human body is disclosed. A catheter in accordance with the present invention comprises a first elongate shaft having a proximal end, a distal end, and a lumen extending therethrough, a second elongate shaft disposed within the lumen of the first elongate shaft, the first elongate shaft including a first helical member comprising a plurality of turns, the second elongate shaft including a second helical member comprising a plurality of turns. Wherein, at least one turn of the second helical member is disposed proximate at least one turn of the first helical member.
摘要:
The application provides devices that can be used to deliver a therapeutic agent to a treatment site within the vessel of a patient at increased pressure, while limiting the contact with and pressure placed on the vessel walls. Devices according to the application include an expandable structure (100) arranged around and on a tube (130) having a lumen (140). The expandable structure may include a sealing ring (111) that makes contact with the interior surface of a vessel to prevent or decrease fluid flow during delivery of a therapeutic agent. This allows delivery of a therapeutic agent with decreased risk of injury to the treatment site. The application also provides for large lumen diameters, preventing shearing stress on therapeutic agents such as cell slurries.
摘要:
Devices and methods for delivering therapeutic or diagnostic agents to a target tissue of a human body are disclosed. A catheter in accordance with the present invention includes an elongate shaft having a distal end, a proximal end, and a lumen therethrough. An elongate shaft includes a first curved portion proximate the distal end of the elongate shaft. The first curved portion of the elongate shaft defines a first plane. The elongate shaft also includes a second curved portion disposed between the distal end of the elongate shaft and the first curved portion of the elongate shaft defines a second plane. The second plane intersects the first plane at an angle.
摘要:
An apparatus for the injection of therapeutic and other agents at a target site within a patient's body. A catheter including a first elongated shaft having a distal end and a proximal end and a lumen extending therebetween. The catheter also including a second elongated shaft slidingly disposed in the first elongated shaft, the second elongated shaft having a distal end and a proximal and a lumen extending therebetween. The catheter further including a third elongated shaft disposed in and attached to the second elongate shaft, the third elongated shaft to move in a one-to-one relationship with the first elongated shaft and the second elongated shaft to maintain a predetermined needle deployment length as each are subjected to various bend configurations.
摘要:
A catheter having a drug delivery unit at the distal end thereof. The drug delivery unit includes an actuator capable of assuming an activated and an inactivated configuration. The drag delivery unit also includes a receptacle capable of accepting a therapeutic agent. The actuator and receptacle are in communication with each other such that the actuator transmits force to the receptacle and the receptacle accepts force from the actuator in an activated configuration of the actuator. Also provided is a method of delivering a therapeutic agent to a target site using the catheter of the present invention.
摘要:
A catheter handpiece apparatus and method for delivering a desired dose with minimal potential for contamination of the injected substance and rapid, accurate delivery of the desired dose. In one embodiment, a carriage assembly affixed to an inner lumen is slidably located within a handpiece housing equipped with an outer lumen. The carriage assembly receives a dose carpule. An actuator knob cocks the carriage assembly and a spring-powered actuator mechanism. After the catheter is maneuvered to a desired injection site and a desired dose is set, depressing a first trigger causes the inner lumen tip to extend beyond the outer lumen into the injection site. Depressing a second trigger causes the actuator mechanism to push the desired dose from the dose carpule through the inner lumen into the injection site. A second embodiment provides a catheter handpiece with a carriage assembly cocking lever and an operator-powered dose delivery mechanism.
摘要:
The present invention is devices, and methods for increasing blood perfusion within the myocardium of the heart (20) by wounding the myocardium, and applying growth factors (34) to promote vascularization. One method includes driving spikes (66) into the myocardium from within the heart with the spikes(66) being formed of biodegradable material containing releasable growth factors (34) having lumens (70), and side holes (74). An alternative method promotes vascularization by injecting angiogenic material into holes (74) bored into the myocardium, and leaving a patent hole. Another method includes injecting angiogenic material into the myocardium without boring, and leaving no patent hole. The angiogenic material can be carried in a biodegradable adhesive. Revascularization of the myocardium is promoted in one method by externally wounding the heart, and applying a patch (90) including growth factors.