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1.发明公开Antibiotic c-7 catechol-subtituted cephalosporin compounds, compositions, and use thereof 失效抗生素C-7-Katechol取代物头孢菌素Bindungen，Präparateund ihre Verwendung。
公开(公告)号：EP0472060A2
公开(公告)日：1992-02-26
申请号：EP91113363.5
申请日：1991-08-08
IPC分类号： C07D501/46 , C07D501/22 , C07D501/24 , A61K31/545
CPC分类号： C07D501/00
摘要： The present invention relates to new cephalosporins of the formula
wherein
R¹ and R² are hydrogen or carboxy, with the proviso that both cannot be the same;
R³ is hydrogen or acetyl; and
R⁴ is a radical selected from the group consisting of
or -CH=CH-CH₂-R⁶
in which n is 1 or 2, R⁵ is hydrogen or acetyl, and R⁶ is hydrogen, a lower C₁₋₃ alkyl, or a radical selected from the group consisting of
in which n and R⁵ are as defined above.
In another aspect, this invention relates to processes for the preparation of the compounds of Formula I, to pharmaceutical compositions containing at least one compound of Formula I, and to intermediates in their preparation.摘要翻译： 本发明涉及式CHEM的新型头孢菌素，其中R 1和R 2为氢或羧基，条件是两者不能相同; R 3是氢或乙酰基; 并且R 4是选自下列的基团：CHEM或-CH = CH-CH 2 -R 6，其中n为1或2，R 5为氢或乙酰基，R 6为 >是氢，低级C 1-3烷基或选自下列基团的基团：其中n和R 5如上定义的
。 在另一方面，本发明涉及制备式I化合物的方法，含有至少一种式I化合物的药物组合物及其制备中的中间体。 -
2.发明公开Antibiotic c-7 catechol-subtituted cephalosporin compounds, compositions, and use thereof 失效抗生素C-7 CATECHOL受体CEPHOROSPORIN化合物，组合物及其用途
公开(公告)号：EP0472060A3
公开(公告)日：1992-08-19
申请号：EP91113363.5
申请日：1991-08-08
IPC分类号： C07D501/46 , C07D501/22 , C07D501/24 , A61K31/545
CPC分类号： C07D501/00
摘要： The present invention relates to new cephalosporins of the formula
wherein
R¹ and R² are hydrogen or carboxy, with the proviso that both cannot be the same;
R³ is hydrogen or acetyl; and
R⁴ is a radical selected from the group consisting of
or -CH=CH-CH₂-R⁶
in which n is 1 or 2, R⁵ is hydrogen or acetyl, and R⁶ is hydrogen, a lower C₁₋₃ alkyl, or a radical selected from the group consisting of
in which n and R⁵ are as defined above. In another aspect, this invention relates to processes for the preparation of the compounds of Formula I, to pharmaceutical compositions containing at least one compound of Formula I, and to intermediates in their preparation.
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