专利检索 ap:("CHUGAI PHARMACEUTICAL CO LTD") AND inv:"MATSUMOTO YOSHIHIRO" 第 1 页

1.

发明公开
RECONSTITUTED HUMAN ANTIBODY AGAINST HUMAN INTERLEUKIN-8 失效
标题翻译：反对人白细胞介素8看，重组人抗体

公开(公告)号：EP0770628A4

公开(公告)日：2004-10-27

申请号：EP95925116

申请日：1995-07-12

申请人： CHUGAI PHARMACEUTICAL CO LTD

发明人： MATSUSHIMA KOUJI , MATSUMOTO YOSHIHIRO , YAMADA YOSHIKI , SATO KOH , TSUCHIYA MASAYUKI , YAMAZAKI TATSUMI

IPC分类号： C07K16/24 , C12N15/13 , C12P21/08 , A61K39/395

CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2319/00

摘要： A reconstituted human antibody against human interleukin-8 (IL-8), comprising (A) L chains comprising: (1) the human L-chain C region, and (2) the L-chain V region containing the human L-chain FR and the L-chain CDR of a mouse monoclonal antibody against IL-8; and (B) H chains comprising: (1) the human H-chain C region, and (2) the H-chain V region containing the human H-chain FR and the H-chain CDR of a mouse monoclonal antibody against IL-8. As the major part of the reconstituted antibody derives from a human antibody and antigenicity of the CDR is low, this antibody has a low antigenicity against the human body, thus being expected to be applicable for medical therapy.