公开(公告)号：EP0770628A4

公开(公告)日：2004-10-27

申请号：EP95925116

申请日：1995-07-12

申请人： CHUGAI PHARMACEUTICAL CO LTD

发明人： MATSUSHIMA KOUJI ,  MATSUMOTO YOSHIHIRO ,  YAMADA YOSHIKI ,  SATO KOH ,  TSUCHIYA MASAYUKI ,  YAMAZAKI TATSUMI

IPC分类号： C07K16/24 ,  C12N15/13 ,  C12P21/08 ,  A61K39/395

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00

摘要： A reconstituted human antibody against human interleukin-8 (IL-8), comprising (A) L chains comprising: (1) the human L-chain C region, and (2) the L-chain V region containing the human L-chain FR and the L-chain CDR of a mouse monoclonal antibody against IL-8; and (B) H chains comprising: (1) the human H-chain C region, and (2) the H-chain V region containing the human H-chain FR and the H-chain CDR of a mouse monoclonal antibody against IL-8. As the major part of the reconstituted antibody derives from a human antibody and antigenicity of the CDR is low, this antibody has a low antigenicity against the human body, thus being expected to be applicable for medical therapy.

公开(公告)号：EP2202307A4

公开(公告)日：2012-01-25

申请号：EP08838661

申请日：2008-10-14

申请人： CHUGAI PHARMACEUTICAL CO LTD

发明人： YAMADA YOSHIKI ,  KIYASU TATSUYA ,  TABATA KAZUYUKI ,  KUZUMAKI AKIHIRO ,  YAMASHIRO MAI

IPC分类号： C12N15/09 ,  C12N5/10 ,  C12P21/02

CPC分类号： C07K16/00 ,  C07K2317/56 ,  C12N2510/02

摘要： The present invention provides a method of producing a recombinant antibody efficiently and at low cost. Disclosed is a method of producing an antibody or a fragment thereof, comprising allowing a cell to produce the antibody or the fragment, wherein the cell contains a larger number of copies of an exogenous DNA encoding the light chain or a fragment thereof of the antibody than the number of copies contained in the cell of an exogenous DNA encoding the heavy chain or a fragment thereof of the antibody. The present invention also provides a recombinant vector comprising one copy of a DNA encoding the heavy chain or a fragment thereof of an antibody and two or more copies of a DNA encoding the light chain or a fragment thereof of the antibody; and a transformant.

公开(公告)号：EP1731032A4

公开(公告)日：2009-10-28

申请号：EP05727975

申请日：2005-03-31

申请人： CHUGAI PHARMACEUTICAL CO LTD

发明人： KODAMA TATSUHIKO ,  YAMADA YOSHIKI ,  KAMADA NOBUO ,  JISHAGE KOU-ICHI

IPC分类号： A01K67/027 ,  C07K16/00 ,  C07K16/18 ,  C12N15/09 ,  C12N15/85

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2217/052 ,  A01K2267/01 ,  A01K2267/02 ,  A01K2267/03 ,  C07K14/005 ,  C07K16/00 ,  C12N2710/14022

公开(公告)号：EP1514928A4

公开(公告)日：2009-08-05

申请号：EP03733287

申请日：2003-06-04

申请人： CHUGAI PHARMACEUTICAL CO LTD

发明人： KODAMA TATSUHIKO ,  JISHAGE KOU-ICHI ,  KAMADA NOBUO ,  YAMADA YOSHIKI

IPC分类号： A01K67/027 ,  A61K38/11 ,  C07K14/01 ,  C07K16/00 ,  C07K16/18 ,  C07K16/30 ,  C12N15/85 ,  C12N15/09 ,  C07K16/08 ,  C12N5/16

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/02 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/5256 ,  C07K14/005 ,  C07K16/00 ,  C07K16/18 ,  C07K16/3076 ,  C12N2710/14122

摘要： A method of producing an antibody which involves the step of administering an immunogen containing a target antigen and a background antigen to a transgenic animal having a gene encoding the background antigen transferred thereinto. Because of being immunotolerant to the background antigen, the transgenic animal effectively produces an antibody against the target antigen.

公开(公告)号：EP1621553A4

公开(公告)日：2006-08-23

申请号：EP04723785

申请日：2004-03-26

申请人： CHUGAI PHARMACEUTICAL CO LTD

发明人： KODAMA TATSUHIKO ,  HAMAKUBO TAKAO ,  SAITOH RYOICHI ,  YAMADA YOSHIKI

IPC分类号： C07K16/18 ,  A61K39/395 ,  A61P35/00 ,  A61P43/00 ,  C12N15/00 ,  C12P21/08

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/76

摘要： As the results of intensive studies, it is found out that antibodies binding to PepT are capable of inhibiting the transportation activity of a peptide transporter. These antibodies are usable as cell proliferation inhibitors in, for example, treating and preventing cancer.