公开(公告)号：EP4034676A1

公开(公告)日：2022-08-03

申请号：EP21755018.5

申请日：2021-07-29

申请人： Cambridge Epigenetix Limited

发明人： BALASUBRAMANIAN, Shankar ,  FULLGRABE, Jens ,  GOSAL, Walraj Singh ,  HOLBROOK, Joanna Dawn ,  LIU, Sidong ,  MORLEY, David ,  NENTWICH, Oliver ,  OST, Tobias ,  STEWARD, Michael ,  VILELLA, Albert ,  WALKER, Nicholas James ,  YU, Shirong ,  BIGNELL, Helen Rachel ,  SAN-BENTO, Rita Santo

IPC分类号： C12Q1/6869

公开(公告)号：EP4083231A1

公开(公告)日：2022-11-02

申请号：EP22170290.5

申请日：2021-07-29

申请人： Cambridge Epigenetix Limited

发明人： BALASUBRAMANIAN, Shankar ,  FULLGRABE, Jens ,  GOSAL, Walraj Singh ,  HOLBROOK, Joanna Dawn ,  LIU, Sidong ,  MORLEY, David ,  NENTWICH, Oliver ,  OST, Tobias ,  STEWARD, Michael ,  VILELLA, Albert ,  WALKER, Nicholas James ,  YU, Shirong ,  BIGNELL, Helen Rachel ,  SAN-BENTO, Rita Santo

IPC分类号： C12Q1/6869

摘要： Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.