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    NOVEL 2,6-DIAMINOPYRIMIDINE DERIVATIVE
    1.
    发明公开
    NOVEL 2,6-DIAMINOPYRIMIDINE DERIVATIVE 审中-公开
    中和剂2,6-二氨基嘧啶衍生物

    公开(公告)号：EP3042899A1

    公开(公告)日：2016-07-13

    申请号：EP14842654.7

    申请日：2014-09-01

    申请人： Carna Biosciences, Inc.

    发明人： KAWAHATA, Wataru ,  ASAMI, Tokiko ,  SAWA, Masaaki ,  IRIE, Takayuki

    IPC分类号： C07D401/10 ,  C07D401/14 ,  A61K31/506 ,  A61K31/5377 ,  A61P19/08 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06

    CPC分类号： C07D403/14 ,  C07D401/10 ,  C07D401/14

    摘要： To provide a novel 2,6-diaminopyrimidine derivative by the following formula (I):
    A 2,6-diaminopyrimidine derivative is represented by the formula (I):

    wherein
    R 1 represents a substituted or unsubstituted lower alkyl group, or a substituted or unsubstituted alkoxy group,
    Ar represents a substituted or unsubstituted aryl group, or a substituted or unsubstituted heteroaryl group,
    Z 1 and Z 2 represent carbon atoms, or either 1 or 2 of the Z 1 and Z 2 represent nitrogen atoms,
    Q is selected from a structure (a) or (b) described below:

    R 2 represents a substituted or unsubstituted lower alkyl group, or a substituted or unsubstituted cycloalkyl group,
    R 3 represents a hydrogen atom or a halogen atom,
    Y represents a nitrogen atom or a carbon atom, and
    the bond drawn with a dotted line parallel to a solid line on structure (a) represents either double bond or single bond.

    摘要翻译： 通过下式（I）提供新的2,6-二氨基嘧啶衍生物：2,6-二氨基嘧啶衍生物由式（I）表示：其中R 1表示取代或未取代的低级烷基，或取代或未取代的 未取代的烷氧基，Ar表示取代或未取代的芳基或取代或未取代的杂芳基，Z 1和Z 2表示碳原子，或者1或2的Z 1和Z 2表示氮原子，Q选自 下述结构（a）或（b）：R 2表示取代或未取代的低级烷基或取代或未取代的环烷基，R 3表示氢原子或卤素原子，Y表示氮原子或碳 原子，并且用结构（a）上平行于实线的虚线绘制的键表示双键或单键。

    NOVEL TRIAZINE DERIVATIVE
    2.
    发明公开
    NOVEL TRIAZINE DERIVATIVE 审中-公开
    新的三嗪衍生物

    公开(公告)号：EP2824099A1

    公开(公告)日：2015-01-14

    申请号：EP13758233.4

    申请日：2013-03-07

    申请人： Carna Biosciences, Inc.

    发明人： KAWAHATA, Wataru ,  ASAMI, Tokiko ,  SAWA, Masaaki ,  ASAMITSU, Yuko ,  IRIE, Takayuki ,  MIYAKE, Takahiro ,  KIYOI, Takao

    IPC分类号： C07D251/42 ,  A61K31/53 ,  A61K31/5377 ,  A61P19/00 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/06 ,  A61P43/00

    CPC分类号： C07D513/04 ,  A61K31/53 ,  A61K31/5377 ,  C07D251/18 ,  C07D251/22 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04

    摘要： To provide a novel triazine derivative represented by the following formula (I):
    A triazine derivative represented by the following formula (I) :

    wherein
    R 1 represents a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocyclic ring, a substituted or unsubstituted heterocyclic fused ring, or a substituted or unsubstituted alkynyl group,
    R 2 represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, or a substituted or unsubstituted alkoxy group,
    R 3 represents a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocyclic ring, or a substituted or unsubstituted heterocyclic fused ring,
    R 4 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted amino group, or a halogen atom, and

    R 5 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, or R 1 and R 5 may be combined to form a saturated or unsaturated 5- to 6-membered ring, thereby forming a multiply fused ring,
    or a pharmaceutically acceptable salt thereof.

    摘要翻译： 为了提供由下式（I）表示的新型三嗪衍生物：由下式（I）表示的三嗪衍生物：其中R1表示取代或未取代的芳基，取代或未取代的杂环，取代或未取代的杂环稠合 环或取代或未取代的炔基，R 2表示氢原子，卤素原子，取代或未取代的低级烷基或取代或未取代的烷氧基，R 3表示取代或未取代的芳基，取代或未取代的杂环 环或取代或未取代的杂环稠环，R 4表示氢原子，取代或未取代的低级烷基，取代或未取代的烷氧基，取代或未取代的氨基或卤素原子，R 5表示氢原子 ，取代或未取代的低级烷基，或者R 1和R 5可以结合形成饱和的 或不饱和的5至6元环，由此形成多重稠环或其药学上可接受的盐。

    NOVEL TRIAZINE DERIVATIVE
    4.
    发明公开
    NOVEL TRIAZINE DERIVATIVE 审中-公开
    新的三嗪衍生物

    公开(公告)号：EP3048102A1

    公开(公告)日：2016-07-27

    申请号：EP14845370.7

    申请日：2014-09-12

    申请人： Carna Biosciences, Inc.

    发明人： MIYAKE, Takahiro ,  KAWAHATA, Wataru ,  ASAMI, Tokiko ,  SAWA, Masaaki

    IPC分类号： C07D401/14 ,  A61K31/53 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00

    CPC分类号： C07D401/14

    摘要： To provide a novel triazine derivative represented by the following formula (I):
    A triazine derivative represented by the following formula (I) :

    wherein
    R 1 represents a substituted or unsubstituted lower alkyl group, or a substituted or unsubstituted alkoxy group,
    Ar represents a substituted or unsubstituted aryl group, or a substituted or unsubstituted heteroaryl group,
    either of Z 1 and Z 2 represents carbon atom and the other is nitrogen atom, or both of the Z 1 and Z 2 represent nitrogen atoms,
    Q is selected from a structure (a) and (b) described below:

    wherein R 2 represents a substituted or unsubstituted lower alkyl group, or a substituted or unsubstituted cycloalkyl group,
    R 3 represents a hydrogen atom or a halogen atom,
    Y represents a nitrogen atom or a carbon atom, and
    the bond drawn with a dotted line parallel to a solid line on structure (a) represents either double bond or single bond,
    or a pharmaceutically acceptable salt thereof.

    摘要翻译： 为了提供由下式（I）表示的新型三嗪衍生物：由下式（I）表示的三嗪衍生物：其中R1表示取代或未取代的低级烷基或取代或未取代的烷氧基，Ar表示取代或未取代的烷氧基 或未取代的芳基，或者取代或未取代的杂芳基，Z 1和Z 2中的任一个表示碳原子且另一个为氮原子，或者Z 1和Z 2都表示氮原子，Q选自结构（a）和 b）：其中R2表示取代或未取代的低级烷基或取代或未取代的环烷基，R3表示氢原子或卤素原子，Y表示氮原子或碳原子， 平行于结构（a）上的实线的虚线表示双键或单键，或其药学上可接受的盐。

    NOVEL TRIAZINE DERIVATIVE
    5.
    发明公开
    NOVEL TRIAZINE DERIVATIVE 审中-公开
    新的三嗪衍生物

    公开(公告)号：EP3026050A1

    公开(公告)日：2016-06-01

    申请号：EP14828654.5

    申请日：2014-07-15

    申请人： Carna Biosciences, Inc.

    发明人： KAWAHATA, Wataru ,  ASAMI, Tokiko ,  SAWA, Masaaki ,  ASAMITSU, Yuko ,  IRIE, Takayuki ,  MIYAKE, Takahiro ,  KIYOI, Takao

    IPC分类号： C07D401/14 ,  A61K31/53 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  A61P37/08

    CPC分类号： C07D401/14 ,  A61K31/53 ,  C07D403/14

    摘要： The purpose of the present invention is to provide a novel triazine derivative of the formula (I):

    wherein
    R 1 represents a substituted or unsubstituted lower alkyl group,
    R 2 represents a hydrogen atom or a substituted or unsubstituted lower alkyl group,
    A represents a nitrogen atom or C-R 3 ,
    R 3 represents a hydrogen atom, a cyano group, a substituted or unsubstituted acyl group, a substituted or unsubstituted sulfonyl group, or a substituted or unsubstituted carbamoyl group, and
    R 4 represents a substituted or unsubstituted lower alkyl group,
    or a substituted or unsubstituted cycloalkyl group,
    or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明的目的是提供一种新的式（Ⅰ）三嗪衍生物或其盐：其中R1代表取代或未取代的低级烷基，R2代表氢原子或取代或未取代的低级烷基，A代表氮原子 或C-R3，R3表示氢原子，氰基，取代或未取代的酰基，取代或未取代的磺酰基或取代或未取代的氨基甲酰基，R4表示取代或未取代的低级烷基，或 取代或未取代的环烷基，或其药学上可接受的盐。