公开(公告)号：EP2519254A2

公开(公告)日：2012-11-07

申请号：EP10800764.2

申请日：2010-12-28

申请人： Centre De Recerca En Salut Internacional De Barcelona ,  Institució Catalana de Recerca i Estudis Avançats ,  Fundació Cellex ,  Hospital Clinic i Provincial de Barcelona

发明人： DEL PORTILLO OBANDO, Hernando, Antonio ,  MARTIN JAULAR, Lorena ,  DEL FERNANDEZ BECERRA, María, Carmen

IPC分类号： A61K39/015

CPC分类号： A61K39/015 ,  C07K14/445 ,  Y02A50/412

摘要： The present invention belongs to the field of vaccines for the prevention and prophylaxis against malaria, more specifically it relates to exosomes isolated from reticulocytes infected with Plasmodium sp., to methods for obtaining them and to the use thereof for the prevention and prophylaxis against malaria as well as to its use for the discovery and identification of novel Plasmodium antigens. The invention also refers to artificial exosomes comprising Plasmodium sp. antigens. Finally, the invention refers to specific antigens discovered by means of the exosomes obtained from reticulocytes infected with Plasmodium sp.

摘要翻译： 本发明属于疫苗用于预防的领域和预防与疟疾，更具体地说，它涉及来自感染疟原虫属网织红细胞分离的外来体，要方法用于获得它们的方法及其用途，用于预防和预防与疟疾如 以及它的新型疟原虫抗原的发现和标识使用。 因此，本发明涉及人工外来体包括疟原虫。 抗原。 最后，本发明涉及一种由感染疟原虫网织红细胞获得外切的方式发现特异性抗原。