公开(公告)号：EP3310761A1

公开(公告)日：2018-04-25

申请号：EP15895847.0

申请日：2015-12-17

申请人： Children's Hospital Medical Center

发明人： ZHENG, Yi ,  CANCELAS, Jose

IPC分类号： C07D215/50 ,  C07D239/48 ,  C07D241/42 ,  C07D403/12

CPC分类号： A01N1/0221 ,  A01N1/0226 ,  C07D209/04 ,  C07D241/40

摘要： Disclosed are compositions and methods for slowing, preventing, or reversing platelet damage, particularly as may occur during blood banking or during refrigeration of platelets. The composition may include one or more of a RAC inhibitor, a CDC42 inhibitor, a RHOA inhibitor, or a combination thereof. The compositions may further include a pharmaceutically acceptable carrier.

公开(公告)号：EP3962896A1

公开(公告)日：2022-03-09

申请号：EP20802505.6

申请日：2020-05-04

申请人： Children's Hospital Medical Center

发明人： NASSAR, Nicolas ,  SEIBEL, William ,  GASILINA, Anjelika ,  CANCELAS, Jose

IPC分类号： C07D231/10 ,  C07D417/14 ,  A61K31/395 ,  A61K31/428