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    MOBILIZATION OF HEMATOPOIETIC CELLS
    1.
    发明公开
    MOBILIZATION OF HEMATOPOIETIC CELLS 审中-公开
    动员多能HÄMAPOIETISCHER干细胞

    公开(公告)号：EP1656156A2

    公开(公告)日：2006-05-17

    申请号：EP04781185.6

    申请日：2004-08-12

    申请人： Children's Hospital Medical Center

    发明人： WILLIAMS, David A. ,  ZHENG, Yi

    IPC分类号： A61K38/00

    CPC分类号： A61K31/522 ,  A61K31/04 ,  A61K31/7088 ,  A61K35/28 ,  A61K38/193 ,  C07K14/4706 ,  C07K2319/01 ,  C12N5/0647 ,  C12N2500/40 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/26

    摘要： Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. The subject's blood can be processed and used to repopulate the destroyed lymphohematopoietic system of a recipient and may in the future be utilized to repair a variety of non-hematopoietic tissues. Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. They can also be used for increasing white blood cell survival and for chemotherapy.

    GTPASE INHIBITORS AND USE THEREOF FOR CONTROLLING PLATELET HYPERACTIVITY
    7.
    发明公开
    GTPASE INHIBITORS AND USE THEREOF FOR CONTROLLING PLATELET HYPERACTIVITY 审中-公开
    GTP酶抑制剂及它们在调节血小板多动症

    公开(公告)号：EP1814553A2

    公开(公告)日：2007-08-08

    申请号：EP05851860.6

    申请日：2005-11-18

    申请人： Children's Hospital Medical Center ,  Girindus America, Inc.

    发明人： ZHENG, Yi ,  AKBAR, Huzoor ,  WILLIAMS, David A. ,  MAZUR, Wieslaw Adam

    IPC分类号： A61K31/505

    CPC分类号： A61K31/506

    摘要： The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools.

    CHIMERIC PEPTIDES FOR THE REGULATION OF GTPASES
    10.
    发明公开
    CHIMERIC PEPTIDES FOR THE REGULATION OF GTPASES 审中-公开
    嵌合肽用于调节GTP酶

    公开(公告)号：EP1656451A2

    公开(公告)日：2006-05-17

    申请号：EP04781214.4

    申请日：2004-08-12

    申请人： Children's Hospital Medical Center

    发明人： ZHENG, Yi ,  WILLIAMS, David A.

    IPC分类号： C12N15/62

    CPC分类号： C07K14/4706 ,  C07K2319/01 ,  C07K2319/02 ,  C07K2319/03 ,  C12N9/14 ,  C12Y306/05002

    摘要： Chimeric peptides or fusion proteins are disclosed that include a RhoGAP activity domain and at least one specificity domain that targets a specific Rho protein. The fusion proteins can be used to inhibit any GTPase activity within a cell. The fusion proteins are particularly advantageous for the treatment of cancer. The present invention generally relates to The present invention generally relates to chimeric peptides capable of regulating GTPases, and more particularly, to methods of targeting individual GTPases by using GTPase-activating proteins. Such proteins may be used for the treatment of cancers and other GTPase-related diseases. This invention relates to nucleic acid molecules and the encoded GTPase activating proteins, and variants thereof, and to the use of these molecules in the characterization, diagnosis, prevention, and treatment of cell signaling, immune, and cell proliferative disorders, particularly cancer. Disclosed herein are compounds and methods for regulating transcription of a selected gene. Methods are provided for constructing and for using such compounds to regulate transcription of a selected gene.