专利检索 ap:("Children's Hospital Medical Center" OR "Girindus America, Inc.") AND inv:"AKBAR, Huzoor" 第 1 页

1.

发明公开
GTPASE INHIBITORS AND USE THEREOF FOR CONTROLLING PLATELET HYPERACTIVITY 审中-公开
标题翻译： GTP酶抑制剂及它们在调节血小板多动症

公开(公告)号：EP1814553A2

公开(公告)日：2007-08-08

申请号：EP05851860.6

申请日：2005-11-18

申请人： Children's Hospital Medical Center , Girindus America, Inc.

发明人： ZHENG, Yi , AKBAR, Huzoor , WILLIAMS, David A. , MAZUR, Wieslaw Adam

IPC分类号： A61K31/505

CPC分类号： A61K31/506

摘要： The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools.