公开(公告)号：EP4053280A1

公开(公告)日：2022-09-07

申请号：EP20880788.3

申请日：2020-06-26

申请人： Daesang Corporation

发明人： SHIN, Won Joo ,  JO, Young Il ,  LEE, Sun Hee ,  KIM, Hyun Young ,  KIM, Yong Soo ,  YANG, Cheol Min

IPC分类号： C12N15/70 ,  C12N9/82 ,  C12P13/22

摘要： Disclosed is a mutant strain having improved aromatic amino acid production capability as a result of the inactivation or weakening of activity of asparaginase which is expressed by ansB gene.

公开(公告)号：EP3904521A1

公开(公告)日：2021-11-03

申请号：EP19905042.8

申请日：2019-12-18

申请人： Daesang Corporation

发明人： LEE, Sun Hee ,  KIM, Hyun Ho ,  KIM, Hyun Young ,  JO, Young Il ,  KIM, Yong Soo ,  YANG, Cheol Min ,  SHIN, Won Joo

IPC分类号： C12N15/70 ,  C12N15/77 ,  C12N15/67 ,  C12P13/04

摘要： The present disclosure relates to an L-amino acid-producing E. coli mutant strain or Corynebacterium glutamicum mutant strain having enhanced L-amino acid productivity, and a method of producing L-amino acid using the same. The L-amino acid-producing E. coli mutant strain and Corynebacterium glutamicum mutant strain according to the present disclosure exhibit an enhanced ability to produce L-amino acid, such as L-tryptophan, L-phenylalanine, L-tyrosine, L-glutamine, L-lysine, L-arginine, L-valine, L-leucine, L-isoleucine, L-threonine, L-histidine, L-serine, or L-citrulline, compared to parent strains thereof, and are capable of producing a high concentration of L-amino acid in high yield.

公开(公告)号：EP4269575A1

公开(公告)日：2023-11-01

申请号：EP21915387.1

申请日：2021-04-26

申请人： Daesang Corporation

发明人： HAN, Jong Yun ,  YANG, Chel Min ,  KIM, Yong Soo ,  JO, Young Il

IPC分类号： C12N9/10 ,  C12N15/70 ,  C12P13/24

摘要： The present invention relates to an E. coli hisG-derived ATP-phosphoribosyltransferase variant having a reduced feedback inhibition by histidine and a strain expressing the same. The variant may maintain its activity even at a high histidine concentration, thus increasing histidine production.

公开(公告)号：EP4159866A1

公开(公告)日：2023-04-05

申请号：EP22190101.0

申请日：2019-12-18

申请人： Daesang Corporation

发明人： LEE, Sun Hee ,  KIM, Hyun Ho ,  KIM, Hyun Young ,  JO, Young Il ,  KIM, Yong Soo ,  YANG, Cheol Min ,  SHIN, Won Joo

IPC分类号： C12N15/70 ,  C12N15/77 ,  C12N15/67 ,  C12P13/04 ,  C07K14/245

摘要： The present disclosure relates to an L-amino acid-producing E. coli mutant strain or Corynebacterium glutamicum mutant strain having enhanced L-amino acid productivity, and a method of producing L-amino acid using the same. The L-amino acid-producing E . coli mutant strain and Corynebacterium glutamicum mutant strain according to the present disclosure exhibit an enhanced ability to produce L-amino acid, such as L-tryptophan, L-phenylalanine, L-tyrosine, L-glutamine, L-lysine, L-arginine, L-valine, L-leucine, L-isoleucine, L-threonine, L-histidine, L-serine, or L-citrulline, compared to parent strains thereof, and are capable of producing a high concentration of L-amino acid in high yield.

公开(公告)号：EP4159865A1

公开(公告)日：2023-04-05

申请号：EP22190099.6

申请日：2019-12-18

申请人： Daesang Corporation

发明人： LEE, Sun Hee ,  KIM, Hyun Ho ,  KIM, Hyun Young ,  JO, Young Il ,  KIM, Yong Soo ,  YANG, Cheol Min ,  SHIN, Won Joo

IPC分类号： C12N15/70 ,  C12N15/77 ,  C12N15/67 ,  C12P13/04 ,  C07K14/245

摘要： The present disclosure relates to an L-amino acid-producing E. coli mutant strain or Corynebacterium glutamicum mutant strain having enhanced L-amino acid productivity, and a method of producing L-amino acid using the same. The L-amino acid-producing E. coli mutant strain and Corynebacterium glutamicum mutant strain according to the present disclosure exhibit an enhanced ability to produce L-amino acid, such as L-tryptophan, L-phenylalanine, L-tyrosine, L-glutamine, L-lysine, L-arginine, L-valine, L-leucine, L-isoleucine, L-threonine, L-histidine, L-serine, or L-citrulline, compared to parent strains thereof, and are capable of producing a high concentration of L-amino acid in high yield.

公开(公告)号：EP4269574A1

公开(公告)日：2023-11-01

申请号：EP21915385.5

申请日：2021-04-26

申请人： Daesang Corporation

发明人： HAN, Jong Yun ,  YANG, Chel Min ,  KIM, Yong Soo ,  JO, Young Il

IPC分类号： C12N9/10 ,  C12N15/70 ,  C12P13/24

摘要： The present invention relates to an E. coli hisG-derived ATP-phosphoribosyltransferase variant having a reduced feedback inhibition by histidine and a strain expressing the same. The variant may maintain its activity even at a high histidine concentration, thus increasing histidine production.

公开(公告)号：EP4053282A1

公开(公告)日：2022-09-07

申请号：EP20882284.1

申请日：2020-06-26

申请人： Daesang Corporation

发明人： SHIN, Won Joo ,  JO, Young Il ,  LEE, Sun Hee ,  KIM, Hyun Young ,  KIM, Yong Soo ,  YANG, Cheol Min

IPC分类号： C12N15/70 ,  C12P13/22

摘要： Disclosed is a mutant strain having improved aromatic amino acid production capability due to inactivation or weakening of activity of an FMN/FAD exporter protein which is expressed by yeeO gene.

公开(公告)号：EP4053281A1

公开(公告)日：2022-09-07

申请号：EP20880789.1

申请日：2020-06-26

申请人： Daesang Corporation

发明人： SHIN, Won Joo ,  JO, Young Il ,  LEE, Sun Hee ,  KIM, Hyun Young ,  KIM, Yong Soo ,  YANG, Cheol Min

IPC分类号： C12N15/70 ,  C12N9/80 ,  C12P13/22

摘要： Provided is a mutant strain having improved aromatic amino acid production capability as a result of inactivation or weakening of activity of glutaminase which is expressed by glutaminase B (glsB) gene.