公开(公告)号：EP3530674A1

公开(公告)日：2019-08-28

申请号：EP17861867.4

申请日：2017-10-19

申请人： Denka Company Limited ,  Tokyo Institute of Technology ,  The Kitasato Institute ,  JAPAN AS REPRESENTED BY THE DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES

发明人： UENO Takafumi ,  YOSHIKAWA Kengo ,  MANO Megumi ,  KATAYAMA, Kazuhiko ,  MIKI, Motohiro ,  TODAKA, Reiko ,  TAKAHASHI, Yoshimasa ,  ONODERA, Taishi

IPC分类号： C07K19/00 ,  A61K39/125 ,  A61P31/12 ,  C07K7/08 ,  C07K14/00 ,  C07K14/005 ,  C07K14/08 ,  C12N15/09 ,  C12P21/02

摘要： The present invention addresses the issue of providing: a norovirus component vaccine for subcutaneous, intradermal, percutaneous, or intramuscular administration, that is capable of easily immunizing target cells; a molecular needle aggregate being an effective component thereof; and a production method therefor. A norovirus component vaccine is provided that has as an effective component thereof an aggregate including a hexamer having two molecules of a trimer of a molecular needle indicated by formula (1) bound thereto. W-L 1 -X n -Y (1) [In the formula, W indicates a P domain amino acid sequence in a norovirus capsid protein that is the immunogen, L 1 indicates a first linker sequence having 0-100 amino acids, X indicates an amino acid sequence of SEQ ID No. 1, Y indicates an amino acid sequence in a cell introduction area, and n indicates an integer of 1-3.]

公开(公告)号：EP4026558A1

公开(公告)日：2022-07-13

申请号：EP20856780.0

申请日：2020-08-26

申请人： Tokyo Institute of Technology ,  The Kitasato Institute ,  Denka Company Limited

发明人： UENO Takafumi ,  NGUYEN Dan Que ,  KATAYAMA Kazuhiko ,  TODAKA Reiko ,  HAGA Kei ,  SAWADA Akihito

IPC分类号： A61K39/12 ,  A61P31/12 ,  C07K14/005 ,  C07K19/00 ,  C12N5/10 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N15/33 ,  C12N15/63

摘要： The present invention addresses the problem of establishing a means for providing a component vaccine that can elicit immunity to a non-structural protein. The present inventors found that this problem can be solved by providing a component vaccine that comprises, as an active ingredient, an aggregate comprising a trimer and/or a hexamer of a molecular needle on which a non-structural protein of a pathogenic virus is supported.