-
1.发明公开Method for cancer therapy with a parvovirus combined with chemotherapy 有权Krebstherapie mit einem Parvovirus in Kombination mit einer Chemotherapie
公开(公告)号：EP2082745A1
公开(公告)日：2009-07-29
申请号：EP07025216.8
申请日：2007-12-28
申请人： Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts , Ruprecht-Karls-Universität Heidelberg
发明人： Rommelaere, Jean , Raykov, Zahari , Schlehofer, Jörg , Kiprijanova, Irina , Heimberger, Tanja , Angelova, Assia , Geletneky, Karsten , Aprahamian, Marc
IPC分类号： A61K35/76 , A61K31/4188 , A61K31/7068 , A61P35/00
CPC分类号： A61K31/495 , A61K31/4188 , A61K31/7068 , A61K35/768 , C12N2750/14032 , A61K2300/00
摘要： Described is a pharmaceutical composition containing (a) a parvovirus and (b) a chemotherapeutic agent, preferably as separate entities. The parvovirus might be based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species. The pharmaceutical composition is beneficial for the treatment of a tumor. Tumors for which a parvovirus or the adjunction of the invention has particular utility include glioma, medulloblastoma, meningioma and pancreatic cancer. Preferred chemotherapeutic agents are gemcitabine and Temozolodine.
摘要翻译： 描述了含有（a）细小病毒和（b）化学治疗剂的药物组合物，优选作为分开的实体。 细小病毒可能基于细小病毒H1，LuIII，小鼠微小病毒（MMV），小鼠细小病毒（MPV），大鼠微小病毒（RMV），大鼠细小病毒（RPV），大鼠病毒（RV），基于上述病毒物种的载体 ，和/或能够积极产生上述病毒物种的细胞。 该药物组合物有利于治疗肿瘤。 细小病毒或本发明的辅助物具有特殊用途的肿瘤包括神经胶质瘤，成神经管细胞瘤，脑膜瘤和胰腺癌。 优选的化学治疗剂是吉西他滨和替莫唑胺。
-
公开(公告)号：EP2082745B1
公开(公告)日：2012-12-19
申请号：EP07025216.8
申请日：2007-12-28
申请人： Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts , Ruprecht-Karls-Universität Heidelberg
发明人： Rommelaere, Jean , Raykov, Zahari , Schlehofer, Jörg , Kiprijanova, Irina , Heimberger, Tanja , Angelova, Assia , Geletneky, Karsten , Aprahamian, Marc
IPC分类号： A61K35/76 , A61K31/4188 , A61K31/7068 , A61P35/00
CPC分类号： A61K31/495 , A61K31/4188 , A61K31/7068 , A61K35/768 , C12N2750/14032 , A61K2300/00
摘要： Described is a pharmaceutical composition containing (a) a parvovirus and (b) a chemotherapeutic agent, preferably as separate entities. The parvovirus might be based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species. The pharmaceutical composition is beneficial for the treatment of a tumor. Tumors for which a parvovirus or the adjunction of the invention has particular utility include glioma, medulloblastoma, meningioma and pancreatic cancer. Preferred chemotherapeutic agents are gemcitabine and Temozolodine.
-
公开(公告)号：EP2431045B1
公开(公告)日：2013-03-06
申请号：EP11003657.1
申请日：2008-12-23
发明人： Rommelaere, Jean , Raykov, Zahari , Schlehofer, Jörg , Kiprijanova, Irina , Heimberger, Tanja , Angelova, Assia , Geletneky, Karsten , Aprahamian, Marc
IPC分类号： A61K35/76 , A61K31/4188 , A61K31/7068 , A61P35/00
CPC分类号： A61K31/495 , A61K31/4188 , A61K31/7068 , A61K35/768 , C12N2750/14032 , A61K2300/00
摘要： Described is a pharmaceutical composition containing (a) a parvovirus and (b) a chemotherapeutic agent, preferably as separate entities. The parvovirus might be based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species. The pharmaceutical composition is beneficial for the treatment of a tumor. Tumors for which a parvovirus or the adjunction of the invention has particular utility include glioma, medulloblastoma, meningioma and pancreatic cancer. Preferred chemotherapeutic agents are gemcitabine and Temozolodine.
-
公开(公告)号：EP2431045A1
公开(公告)日：2012-03-21
申请号：EP11003657.1
申请日：2008-12-23
发明人： Rommelaere, Jean , Raykov, Zahari , Schlehofer, Jörg , Kiprijanova, Irina , Heimberger, Tanja , Angelova, Assia , Geletneky, Karsten , Aprahamian, Marc
IPC分类号： A61K35/76 , A61K31/4188 , A61K31/7068 , A61P35/00
CPC分类号： A61K31/495 , A61K31/4188 , A61K31/7068 , A61K35/768 , C12N2750/14032 , A61K2300/00
摘要： Described is a pharmaceutical composition containing (a) a parvovirus and (b) a chemotherapeutic agent, preferably as separate entities. The parvovirus might be based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species. The pharmaceutical composition is beneficial for the treatment of pancreatic cancer.
摘要翻译： 描述了含有（a）细小病毒和（b）化学治疗剂的药物组合物，优选作为分开的实体。 细小病毒可能基于细小病毒H1，LuIII，小鼠微小病毒（MMV），小鼠细小病毒（MPV），大鼠微小病毒（RMV），大鼠细小病毒（RPV），大鼠病毒（RV），基于上述病毒物种的载体 ，和/或能够积极产生上述病毒物种的细胞。 该药物组合物有利于胰腺癌的治疗。
-
-
-
搜索结果
4 条记录 (耗时 0.013 秒)
