公开(公告)号：EP4381513A1

公开(公告)日：2024-06-12

申请号：EP22761187.8

申请日：2022-08-04

申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts ,  Universität Heidelberg ,  Oxford Nanopore Technologies PLC

发明人： SAHM, Felix ,  SILL, Martin ,  VON DEIMLING, Andreas ,  PFISTER, Stefan ,  JONES, David ,  PATEL, Areeba ,  DOGAN, Helin ,  LOOSE, Matt ,  PAYNE, Alexander

IPC分类号： G16B30/00 ,  G16B40/10 ,  G16B40/20

CPC分类号： G16H50/20 ,  G16B30/00 ,  G16B40/10 ,  G16B40/20

公开(公告)号：EP4335437A1

公开(公告)日：2024-03-13

申请号：EP22194419.2

申请日：2022-09-07

申请人： Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus ,  Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

发明人： GRETEN, Florian ,  DENK, Dominic Pascal ,  PETROCELLI, Valentina ,  BUCHHOLZ, Christian ,  BRAUN, Angela

IPC分类号： A61K31/37 ,  A61P37/02 ,  C12N5/00 ,  C12N5/0783

摘要： The invention is based on the use of Urolithin A for improving mitochondrial health in immune cells such as T-cells. The invention provides new strategies to enhance immune cell based therapies, such as adoptive T-cell therapy. The compounds and compositions of the invention are preferably useful for therapies that involve in vitro T cell modification and expansion, such as modification of T cells with a chimeric antigen receptor (CAR) for treating an antigen associated disorder, such as cancer.

公开(公告)号：EP4301379A2

公开(公告)日：2024-01-10

申请号：EP22713358.4

申请日：2022-03-03

申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

发明人： HALAMA, Niels ,  JÄGER, Dirk ,  SCHMIDT, Patrick

IPC分类号： A61K35/17 ,  A61K35/768 ,  A61P35/00 ,  C07K14/725 ,  C07K16/30 ,  C12N5/0783 ,  A61K39/00

公开(公告)号：EP4138885A1

公开(公告)日：2023-03-01

申请号：EP21719157.6

申请日：2021-04-20

申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

发明人： PAPAVASILIOU, Nina ,  TRILLER, Gianna ,  STEBBINS, Erec ,  VERDI, Joseph

IPC分类号： A61K39/00 ,  A61K39/385 ,  A61P43/00

公开(公告)号：EP4134671A1

公开(公告)日：2023-02-15

申请号：EP21191371.0

申请日：2021-08-13

申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts ,  Universität Heidelberg

发明人： Müller, Michael ,  Oehme, Ina ,  Witt, Olaf ,  Peterziel, Heike ,  Milde, Till

IPC分类号： G01N33/574 ,  A61K31/00

摘要： The present invention relates to a method for identifying a subject susceptible to treatment of cancer by administration of a methylene quinuclidinone agent, said method comprising (a) determining in a sample of said subject at least four biomarkers independently selected from the group consisting of SLC7A11, PLS3, RHBDF1, CLDN1, FAM114A1, YAP1, TJP1, SEPTIN10; COROIA, RHOH, CXCR4, PUM2, TRAF3IP3, KDM2B, PDE7A, ARHGAP9, IKZF1, ACAP1, and PDE7A; (b) comparing the result determined in step (a) to at least one reference, and (c), based on the result of step (b), identifying a subject susceptible to treatment of cancer by administration of a methylene quinuclidinone agent, and to compounds for use, kits, and devices related thereto.

公开(公告)号：EP4130296A1

公开(公告)日：2023-02-08

申请号：EP21189450.6

申请日：2021-08-03

申请人： Deutsches Krebsforschungszentrum - Stiftung des öffentlichen Rechts / Universität Heidelberg

发明人： Schrotz-King, Petra ,  Raut, Janhavi ,  Brenner, Hermann

IPC分类号： C12Q1/6886

摘要： The present invention relates to a method for identifying a subject at risk of developing cancer, said method comprising (a) determining in a sample of said subject the amount of at least one miRNA selected from the list consisting of miR-19a-3p, let-7g-5p, miR-23a-3p, miR-92a-3p, miR-144-5p, and miR-27a-3p; (b) comparing said amount or amounts determined in step (a) to a reference or to references; and (c) identifying a subject at risk of developing cancer based on the result of comparing step (b), and to methods, kits, devices, and systems related thereto.

公开(公告)号：EP4115429A1

公开(公告)日：2023-01-11

申请号：EP21709039.8

申请日：2021-03-05

申请人： Universität Heidelberg ,  DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS

发明人： NICKEL, Felix ,  PETERSEN, Jens ,  ONOGUR, Sinan ,  SCHMIDT, Mona ,  KOWALEWSKI, Karl-Friedrich ,  EISENMANN, Matthias ,  THIEL, Christoph ,  TRENT, Sarah ,  WEBER, Christian

IPC分类号： G16H20/30 ,  G09B9/00 ,  G16H30/40 ,  G09B23/28

公开(公告)号：EP4089183A1

公开(公告)日：2022-11-16

申请号：EP22167943.4

申请日：2015-07-09

申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

发明人： de Villiers-zur Hausen, Ethel-Michele ,  zur Hausen, Harald ,  Gunst, Karin ,  Whitley, Corinna ,  Lamberto, Pérez Iranzu

IPC分类号： C12Q1/6883 ,  C12Q1/70 ,  C12Q1/6886

摘要： Described are HCBI (Healthy Cattle Blood Isolate), MSBI (Multiple Sclerosis Brain Isolate), MSSI (Multiple Sclerosis Serum Isolate) and CMI (Cow Milk Isolate) nucleotide sequences as well as probes and primers comprising part of said nucleotide sequences and antibodies against polypeptides encoded by said nucleotide sequences. Said compounds are useful as early markers for the future development of cancer and diseases of the CNS (Multiple sclerosis MS, Prion-linked diseases, amyotrophic lateral sclerosis, transmissible spongiforme encephalitis, Parkinson's disease, Alzheimer disease) and should represent targets for treatment and prevention.

公开(公告)号：EP4073273A1

公开(公告)日：2022-10-19

申请号：EP20823800.6

申请日：2020-12-10

申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

发明人： BOEHME, Alexander ,  TRUMP, Saskia ,  SOMARRIBAS PATTERSON, Luis Felipe ,  SADIK, Ahmed ,  OPITZ, Christiane A.

IPC分类号： C12Q1/6886

公开(公告)号：EP4049031A1

公开(公告)日：2022-08-31

申请号：EP20806938.5

申请日：2020-10-22

申请人： Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts ,  Berliner Institut für Gesundheitsforschung Zentrum Digitale Gesundheit

发明人： KALLENBERGER, Stefan ,  TREIS, Tim ,  DI PONZIO, Chiara ,  EILS, Roland

IPC分类号： G01N33/50 ,  G01N35/00 ,  G06K9/00 ,  G06T7/00 ,  G16H20/10 ,  G16H40/40