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1.发明授权2-ARYL-2-FLUOROPROPANOIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权2-芳基-2- FLUOR丙烷羧酸及其衍生物，和含有药物组合物
公开(公告)号：EP2094638B1
公开(公告)日：2012-08-08
申请号：EP07859111.2
申请日：2007-12-18
申请人： Dompe' S.P.A.
IPC分类号： C07C59/88 , C07C233/11 , C07C309/65 , C07D277/42
CPC分类号： C07D277/42 , C07B2200/07 , C07C59/88 , C07C235/78 , C07C309/65 , C07C311/51 , C07D207/09 , C07D295/027 , C07D295/13
摘要： The present invention relates to (R,S) 2-aryl-2-fluoropropanoic acids, their single enantiomers (R) and (S), their derivatives amides and acylsulfonamides and to pharmaceutical compositions containing them, which are used in the prevention and treatment of tissue damage due to the exacerbated recruitment of polymorphonucleated neutrophils (PMN leukocytes) at inflammation sites. The present invention provides compounds for use in the treatment of psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the treatment of damages caused by ischemia and reperfusion.
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2.发明授权(2R)-2-[(4-SULFONYL)AMINOPHENYL]PROPANAMIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权（2R）-2 - [（4-磺基）氨基]苯基]丙酰胺在化学式ZUSAMMENSETZUNGEN，DIEE ENTHALTEN
公开(公告)号：EP2024329B1
公开(公告)日：2013-07-31
申请号：EP07729254.8
申请日：2007-05-17
申请人： Dompe' S.P.A.
发明人： ALLEGRETTI, Marcello , BERTINI, Riccardo , BIZZARRI, Cinzia , CESTA, Maria Candida , ARAMINI, Andrea , MORICONI, Alessio
IPC分类号： C07C311/08 , C07C311/09 , C07C311/13 , C07C311/14 , C07C311/21 , C07C311/29 , C07D277/46 , C07D333/34 , A61K31/18 , A61P11/00
CPC分类号： C07C311/08 , C07B2200/07 , C07C311/09 , C07C311/13 , C07C311/14 , C07C311/21 , C07C311/29 , C07C2601/02 , C07C2601/08 , C07D277/46 , C07D333/34
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