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公开(公告)号：EP0846769A3
公开(公告)日：1999-11-24
申请号：EP97309702.5
申请日：1997-12-02
发明人： Hoskins, Jo Ann , Norris, Franklin Harpold , Rockey, Pamela Kay , Rosteck, Paul Robert, Jr. , Skatrud, Paul Luther , Treadway, Patti Jean , Bellido, Michele Louise Young , Wu, Chyun-Yeh Earnest
IPC分类号： C12N15/61 , C12N9/90 , C07K14/315 , C12Q1/533
CPC分类号： C12Q1/533 , C12N9/90 , Y10S530/82 , Y10S530/825
摘要： The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murI of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the MurI enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.
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公开(公告)号：EP0837132A3
公开(公告)日：1999-11-24
申请号：EP97308288.6
申请日：1997-10-17
发明人： Hoskins, Jo Ann , Jaskunas, Stanley Richard, Jr. , Norris, Franklin Harpold , Rockey, Pamela Kay , Rosteck, Paul Robert, Jr. , Zhao, Genshi
IPC分类号： C12N15/31 , C07K14/315 , C12N1/20 , G01N33/566
CPC分类号： C07K14/3156 , A61K38/00
摘要： The invention provides isolated nucleic acid compounds encoding a novel high molecular weight PBP of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the PBP and a method for identifying compounds that bind and/or inhibit the enzymatic activity of the PBP.
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公开(公告)号：EP0846769A2
公开(公告)日：1998-06-10
申请号：EP97309702.5
申请日：1997-12-02
发明人： Hoskins, Jo Ann , Norris, Franklin Harpold , Rockey, Pamela Kay , Rosteck, Paul Robert, Jr. , Skatrud, Paul Luther , Treadway, Patti Jean , Bellido, Michele Louise Young , Wu, Chyun-Yeh Earnest
IPC分类号： C12N15/61 , C12N9/90 , C07K14/315 , C12Q1/533
CPC分类号： C12Q1/533 , C12N9/90 , Y10S530/82 , Y10S530/825
摘要： The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murI of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the MurI enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.
摘要翻译： 本发明提供编码肺炎链球菌的干肽生物合成基因murI的分离的核酸化合物。 还提供了用于表达MurI酶产物的载体和转化的异源宿主细胞，以及用于鉴定抑制干肽生物合成的化合物的方法。
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公开(公告)号：EP0837132A2
公开(公告)日：1998-04-22
申请号：EP97308288.6
申请日：1997-10-17
发明人： Hoskins, Jo Ann , Jaskunas, Stanley Richard, Jr. , Norris, Franklin Harpold , Rockey, Pamela Kay , Rosteck, Paul Robert, Jr. , Zhao, Genshi
IPC分类号： C12N15/31 , C07K14/315 , C12N1/20 , G01N33/566
CPC分类号： C07K14/3156 , A61K38/00
摘要： The invention provides isolated nucleic acid compounds encoding a novel high molecular weight PBP of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the PBP and a method for identifying compounds that bind and/or inhibit the enzymatic activity of the PBP.
摘要翻译： 本发明提供编码肺炎链球菌新型高分子量PBP的分离的核酸化合物。 还提供了用于表达PBP的载体和转化的异源宿主细胞，以及用于鉴定结合和/或抑制PBP的酶活性的化合物的方法。
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