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公开(公告)号：EP2417124B1
公开(公告)日：2013-12-18
申请号：EP10713753.1
申请日：2010-04-06
发明人： DREYFUS, Nicolas, Jacques, Francois , FILLA, Sandra, Ann , JOHANSSON, Anette, Margareta , MASQUELIN, Thierry, J. , SHAH, Jikesh, Arvind , TROMICZAK, Eric, George , WALTER, Magnus, Wilhelm
IPC分类号： C07D401/12 , A61P25/00 , A61K31/4439
CPC分类号： C07D401/12 , A61K31/4439
摘要： A serotonin and norepinephrine reuptake inhibitor of the formula: its uses, and methods for its preparation are described.
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公开(公告)号：EP2646437A1
公开(公告)日：2013-10-09
申请号：EP11787778.7
申请日：2011-11-17
IPC分类号： C07D471/04 , A61K31/437 , A61P25/16
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention provides certain 3-substituted-6-(pyridinylmethoxy)-pyrrolopyridine compounds, particularly compounds of formula I and pharmaceutical compositions thereof. The invention further provides methods of using a compound of formula I to treat Parkinsons disease Formula (I).
摘要翻译： 本发明提供某些3-取代-6-（吡啶基甲氧基） - 吡咯并吡啶化合物，特别是式I化合物及其药物组合物。 本发明进一步提供使用式I化合物治疗帕金森病疾病的式（I）的方法。
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3.发明公开3-AMINOPIPERIDINES AND 3-AMINOQUINUCLIDINES AS INHIBITORS OF MONOAMINE UPTAKE 审中-公开3氨基哌啶和3 aminoquinuclidines AS MONO阿明记录抑制剂
公开(公告)号：EP1638560A1
公开(公告)日：2006-03-29
申请号：EP04751759.4
申请日：2004-05-25
发明人： BEADLE, Christopher, David , CASES-THOMAS, Manuel, Javier , CLARK, Barry, Peter Eli Lilly and Company Limited , GALLAGHER, Peter, Thaddeus , MASTERS, John, Joseph , TIMMS, Graham, Henry Eli Lilly and Company , WALTER, Magnus, Wilhelm , WHATTON, Maria, Ann Eli Lilly and Company Limited , WOOD, Virginia, Ann Eli Lilly and Company Limited , GILMORE, Jeremy Eli Lilly and Company Limited
IPC分类号： A61K31/439 , C07D453/02 , A61K31/4462 , C07D211/56 , C07D405/12
CPC分类号： C07D405/12 , C07D211/56 , C07D453/02
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful for the inhibition of the uptake of one or more physiologically active monoamines (serotonin, norepinephrine, and dopamine).
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公开(公告)号：EP2646437B1
公开(公告)日：2014-09-03
申请号：EP11787778.7
申请日：2011-11-17
IPC分类号： C07D471/04 , A61K31/437 , A61P25/16
CPC分类号： C07D487/04 , C07D471/04
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公开(公告)号：EP2417124A2
公开(公告)日：2012-02-15
申请号：EP10713753.1
申请日：2010-04-06
发明人： DREYFUS, Nicolas, Jacques, Francois , FILLA, Sandra, Ann , JOHANSSON, Anette, Margareta , MASQUELIN, Thierry, J. , SHAH, Jikesh, Arvind , TROMICZAK, Eric, George , WALTER, Magnus, Wilhelm
IPC分类号： C07D401/12 , A61P25/00 , A61K31/4439
CPC分类号： C07D401/12 , A61K31/4439
摘要： A serotonin and norepinephrine reuptake inhibitor of the formula: (I) its uses, and methods for its preparation are described.
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公开(公告)号：EP1534694A1
公开(公告)日：2005-06-01
申请号：EP03748975.4
申请日：2003-08-18
发明人： CASES-THOMAS, Manuel, Javier , HAUGHTON, Helen, Louise , LAMAS-PETEIRA, Carlos , OUWERKERK-MAHADEVAN, Sivi , MASTERS, John, Joseph , SIMMONDS, Robin, George , RUDYK, Hélène, Catherine, Eugénie , WALTER, Magnus, Wilhelm
IPC分类号： C07D265/30 , C07D413/10 , A61K31/5375 , A61P25/00
CPC分类号： C07D265/30 , C07D413/10
摘要： Compounds of formula (I) are selective inhibitors of the reuptake of norepinephrine, wherein Rx is H; Ry is H or C1-C4 alkyl; each Rz is independently H or C1-C4 alkyl; X represents O; Y represents OH or OR; R is C1-C4 alkyl; and Ar1 and Ar2 are optionally substituted phenyl or 5- or 6-membered heteroaryl rings.
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