公开(公告)号：EP0996393B1

公开(公告)日：2005-05-18

申请号：EP98935797.5

申请日：1998-07-22

申请人： Edwards Lifesciences Corporation

发明人： CARPENTIER, Alexandre ,  CARPENTIER, Alain ,  LAM, Hung ,  NGUYEN, Thanh ,  HUYNH, Van, Le ,  CUNANAN, Crystal

IPC分类号： A61F2/24

CPC分类号： A61F2/2448 ,  A61F2250/0004 ,  A61F2250/0082

摘要： An expandable annuloplasty ring which may either expand spontaneously, in situ, as the patient grows or be expanded by surgical intervention by balloon dilatation. The distensible annuloplasty ring of the invention may be usable in pediatric patients whose growth, subsequent to surgical implantation of the ring, will necessitate subsequent enlargement of the ring to accommodate growth of the annulus. The ring may include relatively expandable segments to enable the enlargement thereof. The ring segments may include engaging teeth which cooperate with notches or slots formed in the tubes to provide some resistance to ring distention, while preventing collapse of the ring in the opposite direction. The teeth may be of different sizes or shapes to regulate the amount of force needed to expand the ring at different stages of the patient's growth. Alternatively, the adjustable ring includes a solid core of non-elastic material which plastically retains its shape upon natural expansion of the annulus, or after surgical expansion. In one embodiment, segments are coupled together with a discontinuity around the ring periphery. Pivot regions are provided between adjacent segments that, along with the discontinuity, enable the ring to expand upon annulus growth. The discontinuity may be positioned along the anterior side of the ring or around the posterior side. A further version makes use of telescoped segments with no discontinuity. The segments are coupled together with tubular sheaths, and expand without decoupling. A fabric covering may be omitted.

公开(公告)号：EP1429690A1

公开(公告)日：2004-06-23

申请号：EP01973534.9

申请日：2001-09-26

申请人： Edwards Lifesciences Corporation

发明人： HUYNH, Van, Le ,  SCOTT, Michael, J. ,  JOHNSON, Derrick

IPC分类号： A61F2/24

CPC分类号： A61F2/2409

摘要： A sewing ring for prosthetic heart valves that is connected and configured to pivot outward. A biocompatible fabric covering surrounds at least a portion of the sewing ring, and the ring may be exclusively connected to a stent with the fabric. The sewing ring may be generally planar and of uniform thickness, or may be of varying thickness. The fabric may be used to encompass both the stent and the sewing ring, and may be a single piece. A seam may be provided in the fabric as a discrete pivoting line. The sewing ring may be convertible between bi-stable positions. The ring may extend outward in a frusto-conical shape so as to enable inversion between a position facing the inflow end of the valve and a position facing the outflow end of the valve. The sewing ring may have a compliant insert having a celled construction defined by outer walls and inner ribs. A method of implantation, and a method of assembly of the heart valve is also provided.

公开(公告)号：EP0971649B1

公开(公告)日：2002-12-18

申请号：EP98913095.0

申请日：1998-03-25

申请人： Edwards Lifesciences Corporation

发明人： HUYNH, Van, Le ,  NGUYEN, Than ,  LAM, Hung, Ly ,  GUO, Xiaoming, G. ,  KAFESJIAN, Ralph

IPC分类号： A61F2/24

CPC分类号： A61F2/2409 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/0075 ,  Y10S623/90 ,  Y10S623/91

摘要： Improved, adaptable tissue-type heart valves and methods for their manufacture are disclosed wherein a dimensionally stable, pre-aligned tissue leaflet subassembly is formed and its peripheral edge clamped between and attached to an upper shaped wireform and a lower support stent. A variety of adaptable structural interfaces including suture rings, flanges, and conduits may be attached to the support stent with or without an outlet conduit disposed about the wireform to provide a tissue-type heart valve adaptable for use in either a natural heart or in mechanical pumping devices.

公开(公告)号：EP0971650B1

公开(公告)日：2005-01-26

申请号：EP98913330.1

申请日：1998-04-02

申请人： Edwards Lifesciences Corporation

发明人： NGUYEN, Than ,  LAM, Hung, Ly ,  ZHOU, Jianbo ,  ROMERO, Carlos, M. ,  KAFESJIAN, Ralph ,  GUO, Xiaoming, G. ,  HUYNH, Van, Le

IPC分类号： A61F2/24

CPC分类号： A61M25/0133 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2472 ,  Y10S623/90 ,  Y10S623/91 ,  Y10S623/913

摘要： Heart valve leaflet selection methods and apparatuses which subject individual leaflets to loads and measure the resulting deflection to more reliably group leaflets of similar physical characteristics for later assembly in prosthetic heart valves. The deflection testing may be accomplished using a variety of test set ups which are designed to impart a load on the leaflet which simulates the actual loading within a heart valve. The results from a number of deflection tests are used to categorize individual leaflets, which data can be combined with other data regarding the characteristics of the leaflet to better select leaflets for assembly into a multi-leaflet heart valve. In one embodiment, the deflection test is combined with an intrinsic load test, and leaflets having similar deflection and intrinsic load values used in the same heart valve. One apparatus for testing the leaflets includes a frame for securing the arcuate cusp of the leaflet while the straight coapting edge remains free, to simulate the actual leaflet mounting configuration within the heart valve prosthesis. The frame may include a lower portion having a recess for the leaflet and plurality of receptor holes around the peripheral edge of the recess, and an upper portion having a plurality of needles which extend downward through the leaflet and into the receptor holes and secure the edges of the leaflet.

公开(公告)号：EP3046512A1

公开(公告)日：2016-07-27

申请号：EP14846325.0

申请日：2014-09-17

申请人： Edwards Lifesciences Corporation

发明人： ZENG, Qinggang ,  JOHNSON, Derrick ,  HUYNH, Van, Le

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2210/00 ,  A61F2250/006 ,  A61F2310/00389

摘要： A prosthetic heart valve for implant in a human. The valve includes a wireform with undulating inflow cusps and outflow commissure posts to which flexible leaflets attach and coapt in a flow area. Each leaflet may drape over the top of the wireform in the cusp area, but have tabs that each extend underneath the wireform at the commissure posts to be secured along with a tab of an adjacent leaflet. The prosthetic heart valve may also be a dual-wire wireform, with the leaflets sandwiched therebetween. One wireform may be larger than the other, with the leaflets extending over the smaller wireform. The smaller wireform may have commissures that bend radially outward from the larger wireform to provide structure to which the leaflet tabs attach.

摘要翻译： 用于人类植入物的假体心脏瓣膜。 该阀包括具有起伏的流入尖端和流出的合流柱的线形，柔性小叶在流动区域附着和弯曲。 每个小叶可以悬挂在尖端区域的线形顶部，但是在连接柱处具有各自延伸在线形下方的突片，以便与相邻传单的突片一起固定。 假体心脏瓣膜也可以是双线状线形，其间夹着小叶。 一个线形可以比另一个线形大，传单延伸越过较小的线形。 较小的线形可以具有从更大的线形曲线径向向外弯曲的连合，以提供传播片附接到的结构。

公开(公告)号：EP1429690B1

公开(公告)日：2006-11-29

申请号：EP01973534.9

申请日：2001-09-26

申请人： Edwards Lifesciences Corporation

发明人： HUYNH, Van, Le ,  SCOTT, Michael, J. ,  JOHNSON, Derrick

IPC分类号： A61F2/24

CPC分类号： A61F2/2409

摘要： A sewing ring for prosthetic heart valves that is connected and configured to pivot outward. A biocompatible fabric covering surrounds at least a portion of the sewing ring, and the ring may be exclusively connected to a stent with the fabric. The sewing ring may be generally planar and of uniform thickness, or may be of varying thickness. The fabric may be used to encompass both the stent and the sewing ring, and may be a single piece. A seam may be provided in the fabric as a discrete pivoting line. The sewing ring may be convertible between bi-stable positions. The ring may extend outward in a frusto-conical shape so as to enable inversion between a position facing the inflow end of the valve and a position facing the outflow end of the valve. The sewing ring may have a compliant insert having a celled construction defined by outer walls and inner ribs. A method of implantation, and a method of assembly of the heart valve is also provided.