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    DIAGNOSIS OF NEURODEGENERATIVE DISEASES
    3.
    发明公开
    DIAGNOSIS OF NEURODEGENERATIVE DISEASES 有权
    诊断神经退行性疾病

    公开(公告)号：EP1825275A2

    公开(公告)日：2007-08-29

    申请号：EP05823285.1

    申请日：2005-12-07

    申请人： Electrophoretics Limited ,  MEDICAL RESEARCH COUNCIL ,  University College London

    发明人： WARD, Malcolm Andrew ,  COLLINGE, John ,  JACKSON, Graham Stuart ,  MCGREGOR, Emma ,  LEEDS, Nicola Louise ,  CAMPBELL, James ,  WESTBROOK, Jules ,  BYERS, Helen

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6896 ,  G01N2800/52

    摘要： The invention relates to a method of diagnosis of vCJD in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration of a protein in the diagnostic sample, compared with a sample of a control human subject, the protein being: beta-actin (SwissProt Ace. No. P60709), apolipoprotein A-IV precursor (SwissProt Acc. No. P06727); haptoglobin beta-chain consisting of residues 162-406 (SwissProt Acc. No. P00738); haemoglobin beta chain (SwissProt Ace. No. P02023); or alpha-1-antitrypsin (SwissProt Ace. No. P01009); or a decreased concentration of a protein in the diagnostic sample, compared with a sample of a control, normal human subject, the protein being plasma protease (C1) inhibitor precursor (SwissProt Acc. No. P05155); complement component 1, s sub-component (SwissProt Acc. No. P09871); butyrylcholinesterase precursor (SwissProt Acc. No. P06276); complement component C4B (SwissProt Acc. No. P01028); lumican (SwissProt Ace. No. P51884); alpha-fibrinogen precursor (SwissProt Ace. No. P02671); IGHG4 protein (Swiss Prot Ace. No. Q8TC63) or immunoglobulin lambda heavy chain. Other marker proteins are also disclosed.

    DIAGNOSIS OF NEURODEGENERATIVE DISEASES
    4.
    发明公开
    DIAGNOSIS OF NEURODEGENERATIVE DISEASES 有权
    亨廷顿氏病的Monitorierung

    公开(公告)号：EP1825274A2

    公开(公告)日：2007-08-29

    申请号：EP05820667.3

    申请日：2005-12-07

    申请人： Electrophoretics Limited ,  University College London ,  Medical Research Council

    发明人： LEEDS, Nicola, Louise ,  WARD, Malcolm, Andrew ,  McGREGOR, Emma ,  TABRIZI, Sarah, Joanna ,  DALRYMPLE, Annette ,  CAMPBELL, James ,  WESTBROOK, Jules, Arthur ,  BYERS, Helen, Louise

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6896 ,  G01N2800/52

    摘要： The invention relates to a method of diagnosis of Huntington's Disease in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an altered concentration of a protein in the diagnostic sample, compared with a sample of a control human subject, the protein being selected from: Swiss Prot accession number : Protein name; P10909 : Clusterin precursor; P00738 : Haptoglobin precursor; P01009 : Alpha- l-antitrypsin precursor; P01024 : Complement C3 precursor; P01620 : 1g kappa chain V-III region; P01834 : 1g kappa chain C region P01842 : 1g lambda chain C regions; P01857 : 1g gamma-1 chain C region; P01859 : Ig gamma-2 chain C region; P01876 : 1g alpha-1 chain C region P02647 : Apolipoprotein A-I precursor; P02649 : Apolipoprotein E precursor; P02652 : Apolipoprotcin A-II precursor; P02655 : Apolipoprotein C-II precursor; P02656 : Apolipoprotein C-III precursor P02671 : Fibrinogen alpha/alpha-E chain precursor; P02763 : Alpha- l-acid glycoprotein 1 precursor; P02766 : Transthyretin precursor; P02768 : Serum albumin precursor; P02787 : Serotransferrin precursor; P04196 : Histidine-rich glycoprotein precursor; P06727 : Apolipoprotein A-IV precursor; P19652 : Alpha- l-acid glycoprotein 2 precursor; P68871/P02042 : Hemoglobin beta chain/Hemoglobin delta chain; P60709 : Beta actin.