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公开(公告)号：EP2389587A2
公开(公告)日：2011-11-30
申请号：EP10704840.7
申请日：2010-01-26
发明人： LOVESTONE, Simon, Harold , CAMPBELL, James , O'BRIEN, Darragh, Patrick, William , GÜNTERT, Andreas, Christian , BYERS, Helen, Louise
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： The invention provides a method for aiding the diagnosis or prognostic monitoring of Alzheimer's disease in a subject, said method comprising; providing a sample of blood obtained from said patient; assaying the amount of gelsolin present in said sample; comparing the amount of gelsolin present in said sample to a reference amount of gelsolin present in a sample from a healthy subject, wherein detection of a gelsolin level in the sample from said patient which is lower than the gelsolin level in the reference sample indicates an increased likelihood of Alzheimer's disease in said patient.
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公开(公告)号：EP2389587B1
公开(公告)日：2013-12-25
申请号：EP10704840.7
申请日：2010-01-26
发明人： LOVESTONE, Simon, Harold , CAMPBELL, James , O'BRIEN, Darragh, Patrick, William , GÜNTERT, Andreas, Christian , BYERS, Helen, Louise
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： The invention provides a method for aiding the diagnosis or prognostic monitoring of Alzheimer's disease in a subject, said method comprising; providing a sample of blood obtained from said patient; assaying the amount of gelsolin present in said sample; comparing the amount of gelsolin present in said sample to a reference amount of gelsolin present in a sample from a healthy subject, wherein detection of a gelsolin level in the sample from said patient which is lower than the gelsolin level in the reference sample indicates an increased likelihood of Alzheimer's disease in said patient. Other markers are C1 protease inhibitor and ceruloplasmin. Both blood samples and tissue samples have been investigated.
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公开(公告)号：EP1825274B1
公开(公告)日：2009-11-18
申请号：EP05820667.3
申请日：2005-12-07
发明人： LEEDS, Nicola, Louise , WARD, Malcolm, Andrew , McGREGOR, Emma , TABRIZI, Sarah, Joanna , DALRYMPLE, Annette , CAMPBELL, James , WESTBROOK, Jules, Arthur , BYERS, Helen, Louise
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/52
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公开(公告)号：EP1825274A2
公开(公告)日：2007-08-29
申请号：EP05820667.3
申请日：2005-12-07
发明人： LEEDS, Nicola, Louise , WARD, Malcolm, Andrew , McGREGOR, Emma , TABRIZI, Sarah, Joanna , DALRYMPLE, Annette , CAMPBELL, James , WESTBROOK, Jules, Arthur , BYERS, Helen, Louise
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/52
摘要： The invention relates to a method of diagnosis of Huntington's Disease in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an altered concentration of a protein in the diagnostic sample, compared with a sample of a control human subject, the protein being selected from: Swiss Prot accession number : Protein name; P10909 : Clusterin precursor; P00738 : Haptoglobin precursor; P01009 : Alpha- l-antitrypsin precursor; P01024 : Complement C3 precursor; P01620 : 1g kappa chain V-III region; P01834 : 1g kappa chain C region P01842 : 1g lambda chain C regions; P01857 : 1g gamma-1 chain C region; P01859 : Ig gamma-2 chain C region; P01876 : 1g alpha-1 chain C region P02647 : Apolipoprotein A-I precursor; P02649 : Apolipoprotein E precursor; P02652 : Apolipoprotcin A-II precursor; P02655 : Apolipoprotein C-II precursor; P02656 : Apolipoprotein C-III precursor P02671 : Fibrinogen alpha/alpha-E chain precursor; P02763 : Alpha- l-acid glycoprotein 1 precursor; P02766 : Transthyretin precursor; P02768 : Serum albumin precursor; P02787 : Serotransferrin precursor; P04196 : Histidine-rich glycoprotein precursor; P06727 : Apolipoprotein A-IV precursor; P19652 : Alpha- l-acid glycoprotein 2 precursor; P68871/P02042 : Hemoglobin beta chain/Hemoglobin delta chain; P60709 : Beta actin.
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