公开(公告)号：EP3943076A2

公开(公告)日：2022-01-26

申请号：EP21181417.3

申请日：2015-12-17

申请人： Empros Pharma AB

发明人： ALDERBORN, Göran ,  FORSLUND, Anders ,  HOLMBÄCK, Ulf ,  LENNERNÄS, Hans ,  GRUDÉN, Jan, Stefan Persson

IPC分类号： A61K9/50 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K9/48 ,  A61K9/14 ,  A61K9/70 ,  A61K31/365 ,  A61K31/7008 ,  A61K31/702

摘要： The present invention relates to a modified-release oral composition comprising orlistat or acarbose, wherein the composition comprises two individually distinct parts with different release patterns, the composition comprises:
a part, G2B, comprising orlistat, an enteric polymer and a surfactant, and a part, G3, comprising orlistat and one or more of a surfactant, a water-soluble polymer, and a water-swellable polymer, or a part, G1, comprising acarbose and one or more of: a hydrophobic polymer, a lipid and a wax, and a part, G2A, comprising acarbose, an enteric polymer and a surfactant.

公开(公告)号：EP3943076A3

公开(公告)日：2022-04-13

申请号：EP21181417.3

申请日：2015-12-17

申请人： Empros Pharma AB

发明人： ALDERBORN, Göran ,  FORSLUND, Anders ,  HOLMBÄCK, Ulf ,  LENNERNÄS, Hans ,  GRUDÉN, Jan, Stefan Persson

IPC分类号： A61K9/50 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K9/48 ,  A61K9/14 ,  A61K9/70 ,  A61K31/365 ,  A61K31/7008 ,  A61K31/702

摘要： The present invention relates to a modified-release oral composition comprising orlistat or acarbose, wherein the composition comprises two individually distinct parts with different release patterns, the composition comprises:
a part, G2B, comprising orlistat, an enteric polymer and a surfactant, and a part, G3, comprising orlistat and one or more of a surfactant, a water-soluble polymer, and a water-swellable polymer, or a part, G1, comprising acarbose and one or more of: a hydrophobic polymer, a lipid and a wax, and a part, G2A, comprising acarbose, an enteric polymer and a surfactant.

公开(公告)号：EP3233066A1

公开(公告)日：2017-10-25

申请号：EP15813822.2

申请日：2015-12-17

申请人： Empros Pharma AB

发明人： ALDERBORN, Göran ,  FORSLUND, Anders ,  HOLMBÄCK, Ulf ,  LENNERNÄS, Hans ,  GRUDÉN, Jan Stefan Persson

IPC分类号： A61K9/50 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K9/48 ,  A61K9/14 ,  A61K9/70 ,  A61K31/365 ,  A61K31/7008 ,  A61K31/702

CPC分类号： A61K9/2081 ,  A61K9/0053 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/209 ,  A61K9/284 ,  A61K9/2846 ,  A61K9/2853 ,  A61K9/2886 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5047 ,  A61K9/5073 ,  A61K31/365 ,  A61K31/702 ,  A61K2300/00

摘要： The present invention relates to a modified-release composition comprising orlistat and acarbose, comprising individually distinct parts with different release patterns: a) a first part, G1, comprising from about 5 to about 70% w/w of the total dose of acarbose, b) a second part, G2A, comprising from about 30 to about 95% w/w of the total dose of acarbose, c) a third part, G2B, comprising from about 10 to about 90% w/w of the total dose of orlistat, and d) a fourth part, G3, comprising from about 10 to about 80% w/w of the total dose of orlistat, and the total concentration of acarbose and orlistat, respectively, in the composition is 100% w/w.

摘要翻译： 本发明涉及包含奥利司他和阿卡波糖的改良释放组合物，其包含具有不同释放模式的独立不同部分：a）第一部分G1，其包含总剂量约5％至约70％w / w的阿卡波糖， b）第二部分G2A，其包含约30至约95％w / w的阿卡波糖总剂量，c）第三部分G2B，其包含总剂量的约10至约90％w / w 奥利司他，和d）第四部分G3，其分别包含奥利司他总剂量的约10至约80％w / w，并且组合物中阿卡波糖和奥利司他的总浓度为100％w / w。