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公开(公告)号：EP3601259A1
公开(公告)日：2020-02-05
申请号：EP18718381.9
申请日：2018-03-30
发明人： CHAN, Bryan , DROBNICK, Joy , GAZZARD, Lewis , HEFFRON, Timothy , LIANG, Jun , MALHOTRA, Sushant , MENDONCA, Rohan , RAJAPAKSA, Naomi , STIVALA, Craig , TELLIS, John , WANG, Weiru , WEI, BinQing , ZHOU, Aihe , CARTWRIGHT, Matthew W. , LAINCHBURY, Michael , GANCIA, Emanuela , SEWARD, Eileen , MADIN, Andrew , FAVOR, David , FONG, Kin Chiu , HU, Yonghan , GOOD, Andrew
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D487/14 , C07D217/22 , C07D401/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04 , C07D487/04 , C07D491/04 , C07D498/04 , C07D513/04 , C07D519/00
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公开(公告)号：EP3601284A1
公开(公告)日：2020-02-05
申请号：EP18726551.7
申请日：2018-03-30
发明人： CHAN, Bryan , DANIELS, Blake , DROBNICK, Joy , GAZZARD, Lewis , HEFFRON, Timothy , HUESTIS, Malcolm , LIANG, Jun , MALHOTRA, Sushant , MENDONCA, Rohan , RAJAPAKSA, Naomi , SIU, Michael , STIVALA, Craig , TELLIS, John , WANG, Weiru , WEI, BinQing , ZHOU, Aihe , CARTWRIGHT, Matthew W. , GANCIA, Emanuela , JONES, Graham , LAINCHBURY, Michael , MADIN, Andrew , SEWARD, Eileen , FAVOR, David , FONG, Kin Chiu , HU, Yonghan , GOOD, Andrew , HU, Baihua , LU, Aijun
IPC分类号： C07D471/04 , C07D519/00 , A61K31/4375 , A61P35/00
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3.发明授权AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS 有权氨基嘧啶类化合物作为含EGFR突变体的T790M的抑制剂
公开(公告)号：EP2922851B8
公开(公告)日：2017-09-27
申请号：EP13798885.3
申请日：2013-11-19
发明人： BRYAN, Marian C. , CHAN, Bryan , HANAN, Emily , HEFFRON, Timothy , PURKEY, Hans , ELLIOTT, Richard Leonard , HEALD, Robert , KNIGHT, Jamie , LAINCHBURY, Michael , SEWARD, Eileen M.
IPC分类号： C07D471/04 , C07D519/00 , A61K31/542 , A61P35/00
CPC分类号： C07D471/04 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K45/06 , C07D491/107 , C07D498/08 , C07D498/10 , C07D519/00
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公开(公告)号：EP3860995A1
公开(公告)日：2021-08-11
申请号：EP19790382.6
申请日：2019-10-02
发明人： LIANG, Jun , MENDONCA, Rohan V. , SIU, Michael , TELLIS, John , WANG, Weiru , WEI, BinQing , CHAN, Bryan , CHOO, Edna F. , DROBNICK, Joy , GAZZARD, Lewis J. , HEFFRON, Timothy
IPC分类号： C07D471/04 , C07D401/04 , C07D498/04 , A61P35/00 , A61K31/4375
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公开(公告)号：EP3596075A1
公开(公告)日：2020-01-22
申请号：EP18713816.9
申请日：2018-03-14
发明人： HEFFRON, Timothy , MALHOTRA, Sushant , WEI, BinQing , CHAN, Bryan , GAZZARD, Lewis , GANCIA, Emanuela , LAINCHBURY, Michael , MADIN, Andrew , SEWARD, Eileen , HU, Yonghan
IPC分类号： C07D471/04 , A61P35/00 , A61K31/437 , A61K31/5377 , A61K31/496 , A61K31/506
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公开(公告)号：EP3860980A1
公开(公告)日：2021-08-11
申请号：EP19791057.3
申请日：2019-10-02
发明人： LIANG, Jun , MENDONCA, Rohan V. , SIU, Michael , TELLIS, John , WANG, Weiru , WEI, BinQing , CHAN, Bryan , CHOO, Edna F. , DROBNICK, Joy Alison , GAZZARD, Lewis J. , HEFFRON, Timothy
IPC分类号： C07D217/22 , C07D403/14 , C07D407/14 , C07D471/04 , C07D498/04 , A61P35/00 , A61K31/472
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公开(公告)号：EP3052494B1
公开(公告)日：2018-12-26
申请号：EP14740116.0
申请日：2014-06-26
发明人： BRYAN, Marian C. , CHAN, Bryan , DIEDERICH, Francois , DOTSON, Jennafer , HANAN, Emily , HEFFRON, Timothy , LAINCHBURY, Michael , HEALD, Robert , SEWARD, Eileen M.
IPC分类号： C07D471/04 , A61K31/506 , A61P35/00
CPC分类号： C07D471/04 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K45/06 , C07D519/00
摘要： This invention relates to novel compounds which are inhibitors of T790M containing EGFR mutants, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of cancer.
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