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公开(公告)号：EP4397309A3
公开(公告)日：2024-09-04
申请号：EP24152498.2
申请日：2018-07-12
发明人： PATEL, Snahel , HAMILTON, Gregory , ZHAO, Guiling , CHEN, Huifen , DANIELS, Blake , STIVALA, Craig
IPC分类号： C07D487/04 , C07D498/04 , A61P25/16 , A61P25/28 , A61K31/41 , A61K31/437 , A61K31/5365
CPC分类号： C07D487/04 , A61P25/16 , A61P25/28 , C07D498/04 , A61P17/06 , A61P21/00 , A61P19/02 , A61P1/00 , C07D235/12 , C07D471/04
摘要： The invention provides novel compounds having the general formula I:
wherein R', the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.-
公开(公告)号：EP4093509A1
公开(公告)日：2022-11-30
申请号：EP21709504.1
申请日：2021-01-20
发明人： GIBBONS, Paul , LAI, Kwong Wah , NILEWSKI, Christian , PASTOR, Richard M. , STABEN, Steven Thomas , STIVALA, Craig , ZHU, Bing-Yan , CHEN, Huifen
IPC分类号： A61P29/00 , A61P35/00 , C07D498/04 , C07D498/10 , A61K31/424 , A61K31/4439 , A61K31/506 , A61K31/5365
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公开(公告)号：EP3852752A1
公开(公告)日：2021-07-28
申请号：EP19780127.7
申请日：2019-09-19
发明人： MALHOTRA, Sushant , STIVALA, Craig , WEI, BinQing , CHAN, Bryan K. , HEFFRON, Timothy , LAINCHBURY, Michael , MADIN, Andrew , PANCHAL, Terry Aaron , SEWARD, Eileen Mary , BLENCH, Toby , CARTWRIGHT, Matthew W. , DECHAUX, Elsa Amandine , ELLIOTT, Richard , GANCIA, Emanuela
IPC分类号： A61K31/437 , A61P35/00 , C07D471/04
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公开(公告)号：EP3601284A1
公开(公告)日：2020-02-05
申请号：EP18726551.7
申请日：2018-03-30
发明人： CHAN, Bryan , DANIELS, Blake , DROBNICK, Joy , GAZZARD, Lewis , HEFFRON, Timothy , HUESTIS, Malcolm , LIANG, Jun , MALHOTRA, Sushant , MENDONCA, Rohan , RAJAPAKSA, Naomi , SIU, Michael , STIVALA, Craig , TELLIS, John , WANG, Weiru , WEI, BinQing , ZHOU, Aihe , CARTWRIGHT, Matthew W. , GANCIA, Emanuela , JONES, Graham , LAINCHBURY, Michael , MADIN, Andrew , SEWARD, Eileen , FAVOR, David , FONG, Kin Chiu , HU, Yonghan , GOOD, Andrew , HU, Baihua , LU, Aijun
IPC分类号： C07D471/04 , C07D519/00 , A61K31/4375 , A61P35/00
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公开(公告)号：EP3908586A1
公开(公告)日：2021-11-17
申请号：EP20704652.5
申请日：2020-01-09
发明人： PATEL, Snahel , HAMILTON, Gregory , ZHAO, Guiling , CHEN, Huifen , DANIELS, Blake , STIVALA, Craig
IPC分类号： C07D487/04 , A61K31/4196 , A61K31/4439 , A61P1/00 , A61P13/12 , A61P21/00 , A61P25/16 , A61P37/00 , A61P37/06
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6.发明公开
公开(公告)号：EP3760625A1
公开(公告)日：2021-01-06
申请号：EP20169511.1
申请日：2016-07-01
IPC分类号： C07D403/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/10 , C07D495/04 , C07D498/04 , C07D413/14 , C07D491/048 , C07D491/052 , C07D519/00 , A61P1/00 , A61P1/04
摘要： The invention provides compounds having the general formula (I)
wherein R 1 , X, Z 1 , L, n, the A ring, the B ring, and the C ring are as described herein, pharmaceutical compositions including the compounds and the compounds for use in methods of medical treatment.
The present compounds are receptor-interacting protein-1 (RIP1) kinase inhibitors useful for treating e.g. inflammatory diseases, such as e.g. irritable bowel disorders (IBD), irritable bowel syndrome (IBS), Crohn's disease, ulcerative colitis, myocardial infarction, stroke, traumatic brain injury, atherosclerosis, ischemia-reperfusion injury of kidneys, liver and lungs, cisplatin-induced kidney injury, sepsis, systemic inflammatory response syndrome (SIRS), pancreatits, psoriasis, retinitis pigmentosa, retinal degeneration, chronic kidney diseases, acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD).
The present description discloses the preparation of exemplary and reference compounds, as well as pharmacological data thereof (e.g. pages 116 to 1221; examples 1 to 793; examples A to C; tables).
An exemplary compound is e.g. 5a-methyl-N-((S)-5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indazole-3-carboxamide (example 1)-
公开(公告)号：EP3823974A1
公开(公告)日：2021-05-26
申请号：EP19753515.6
申请日：2019-07-19
发明人： MCBRIDE, Christopher , TRZOSS, Lynnie Lin , BOLOOR, Amogh , SOKOLOVA, Nadezda , PASTOR, Richard M. , STABEN, Steven Thomas , STIVALA, Craig , VOLGRAF, Matthew , BRONNER, Sarah M.
IPC分类号： C07D498/04 , A61P29/00 , A61P35/00 , C07D231/24 , C07D413/06 , A61K31/4188 , A61K31/5365 , A61K31/415
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公开(公告)号：EP3601259A1
公开(公告)日：2020-02-05
申请号：EP18718381.9
申请日：2018-03-30
发明人： CHAN, Bryan , DROBNICK, Joy , GAZZARD, Lewis , HEFFRON, Timothy , LIANG, Jun , MALHOTRA, Sushant , MENDONCA, Rohan , RAJAPAKSA, Naomi , STIVALA, Craig , TELLIS, John , WANG, Weiru , WEI, BinQing , ZHOU, Aihe , CARTWRIGHT, Matthew W. , LAINCHBURY, Michael , GANCIA, Emanuela , SEWARD, Eileen , MADIN, Andrew , FAVOR, David , FONG, Kin Chiu , HU, Yonghan , GOOD, Andrew
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D487/14 , C07D217/22 , C07D401/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04 , C07D487/04 , C07D491/04 , C07D498/04 , C07D513/04 , C07D519/00
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公开(公告)号：EP4397309A2
公开(公告)日：2024-07-10
申请号：EP24152498.2
申请日：2018-07-12
发明人： PATEL, Snahel , HAMILTON, Gregory , ZHAO, Guiling , CHEN, Huifen , DANIELS, Blake , STIVALA, Craig
IPC分类号： A61K31/5365
CPC分类号： C07D487/04 , A61P25/16 , A61P25/28 , C07D498/04 , A61P17/06 , A61P21/00 , A61P19/02 , A61P1/00 , C07D235/12 , C07D471/04
摘要： The invention provides novel compounds having the general formula I:
wherein R', the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.-
公开(公告)号：EP3826722A1
公开(公告)日：2021-06-02
申请号：EP19750199.2
申请日：2019-07-23
发明人： LIANG, Jun , MALHOTRA, Sushant , MENDONCA, Rohan V. , RAJAPAKSA, Naomi , SIU, Michael , STIVALA, Craig , TELLIS, John C. , WEI, BinQing , CHAN, Bryan K. , DROBNICK, Joy Alison , GAZZARD, Lewis J. , HEFFRON, Timothy , JONES, Graham , LAINCHBURY, Michael , MADIN, Andrew , SEWARD, Eileen Mary , CARTWRIGHT, Matthew W. , GANCIA, Emanuela , FAVOR, David , FONG, Kin Chiu , GOOD, Andrew , HU, Yonghan
IPC分类号： A61P35/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D498/04 , C07D498/14 , C07D513/04 , C07D515/04 , A61K31/551 , A61K31/554 , A61K31/506 , A61K31/501
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