公开(公告)号：EP2283009B1

公开(公告)日：2012-08-29

申请号：EP09745673.5

申请日：2009-05-06

申请人： F. Hoffmann-La Roche AG

发明人： ARZENO, Humberto Bartolome ,  DUNN, James Patrick ,  GOLDSTEIN, David Michael ,  GONG, Leyi ,  HAN, Xiaochun ,  HOGG, Joan Heather ,  JAHANGIR, Alam ,  PALMER, Wylie Solang ,  REUTER, Deborah Carol ,  SILVA, Tania ,  TIVITMAHAISOON, Parcharee ,  TREJO-MARTIN, Teresa Alejandra ,  WU, Shao-Yong

IPC分类号： C07D401/14 ,  A61K31/506 ,  A61P29/00

CPC分类号： C07D401/14

公开(公告)号：EP2283009A1

公开(公告)日：2011-02-16

申请号：EP09745673.5

申请日：2009-05-06

申请人： F. Hoffmann-La Roche AG

发明人： ARZENO, Humberto Bartolome ,  DUNN, James Patrick ,  GOLDSTEIN, David Michael ,  GONG, Leyi ,  HAN, Xiaochun ,  HOGG, Joan Heather ,  JAHANGIR, Alam ,  PALMER, Wylie Solang ,  REUTER, Deborah Carol ,  SILVA, Tania ,  TIVITMAHAISOON, Parcharee ,  TREJO-MARTIN, Teresa Alejandra ,  WU, Shao-Yong

IPC分类号： C07D401/14 ,  A61K31/506 ,  A61P29/00

CPC分类号： C07D401/14

摘要： The invention relates to prodrugs of JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses prodrugs of JNK inhibitors, as described below in formula (I), wherein m, n, p, q, Q, r, R
1 , R
2 , R
3 , X, X
1 , X
2 , X
3 , X
4 , X
5 , Y
1 , Y
2 , Z
1 , and Z
2 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.