公开(公告)号：EP2742046A1

公开(公告)日：2014-06-18

申请号：EP12748670.2

申请日：2012-08-10

申请人： F.Hoffmann-La Roche AG

发明人： DO, Steven ,  HU, Huiyong ,  KOLESNIKOV, Aleksandr ,  LEE, Wendy ,  TSUI, Vickie Hsiao-Wei ,  WANG, Xiaojing ,  WEN, Zhaoyang

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P9/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4995 ,  A61K31/506 ,  A61K31/55 ,  A61K31/551 ,  A61K45/06 ,  C07D231/00 ,  C07D519/00

摘要： Pyrazolo[3,4-c]pyridine compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein R
1 and R
2 are as defined herein, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

公开(公告)号：EP2867232A1

公开(公告)日：2015-05-06

申请号：EP13731771.5

申请日：2013-06-26

申请人： F.Hoffmann-La Roche AG

发明人： DO, Steven ,  HU, Huiyong ,  KOLESNIKOV, Aleksandr ,  TSUI, Vickie, H. ,  WANG, Xiaojing

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00 ,  A61P3/00 ,  A61P5/00 ,  A61P25/00

CPC分类号： C07D471/04 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/513 ,  A61K31/55 ,  A61K31/551 ,  A61K45/06 ,  C07D471/10 ,  C07D487/10 ,  C07D491/052

摘要： 5-Azaindazole compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.