公开(公告)号：EP2742046A1

公开(公告)日：2014-06-18

申请号：EP12748670.2

申请日：2012-08-10

申请人： F.Hoffmann-La Roche AG

发明人： DO, Steven ,  HU, Huiyong ,  KOLESNIKOV, Aleksandr ,  LEE, Wendy ,  TSUI, Vickie Hsiao-Wei ,  WANG, Xiaojing ,  WEN, Zhaoyang

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P9/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4995 ,  A61K31/506 ,  A61K31/55 ,  A61K31/551 ,  A61K45/06 ,  C07D231/00 ,  C07D519/00

摘要： Pyrazolo[3,4-c]pyridine compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein R
1 and R
2 are as defined herein, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.