公开(公告)号：EP4364747A1

公开(公告)日：2024-05-08

申请号：EP22833260.7

申请日：2022-06-30

申请人： Foundation for Biomedical Research and Innovation at Kobe ,  Japanese Red Cross Society

发明人： TAGUCHI Akihiko ,  TAURA Akie ,  OKINAKA Yuka ,  OGAWA Yuko ,  KIMURA Takafumi ,  TANAKA Mitsunobu ,  YASUI Kazuta ,  Fuchizaki Akihiro ,  YASUI Teruhito

IPC分类号： A61K35/28 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  C12N5/0789

CPC分类号： A61P9/04 ,  A61P9/00 ,  A61P9/10 ,  C12N5/06 ,  A61K35/28

摘要： The present invention relates to a pharmaceutical composition comprising a population of cells including irradiated hematopoietic stem cells, and a method for producing the pharmaceutical composition, specifically, a pharmaceutical composition for treating an ischemic disease, comprising a population of cells including irradiated hematopoietic stem cells, wherein the irradiation is irradiation at 50 Gy or less, and a method for producing the pharmaceutical composition.

公开(公告)号：EP4098266A1

公开(公告)日：2022-12-07

申请号：EP20912688.7

申请日：2020-11-26

申请人： Foundation for Biomedical Research and Innovation at Kobe

发明人： TAGUCHI Akihiko ,  OGAWA Yuko ,  OKINAKA Yuka ,  FUKUSHIMA Masanori ,  YAMANAKA Atsuo

IPC分类号： A61K35/28 ,  A61K35/12 ,  A61K38/18 ,  A61K45/00 ,  A61P25/00 ,  A61P43/00

摘要： The effect of physical exercise performed on a physical function of a subject with an irreversibly reduced physical function is promoted. Bone marrow mononuclear cells, CD34-positive cells, CD133-positive cells, or stem cells are contained. The central and peripheral nerves communicate intimately with each other. When these cells are administered to a subject, and the subject performs an appropriate physical exercise, the reduced physical function can be dramatically improved. The physical exercise is, for example, physical exercise that stimulates both of brain and peripheral nerves based on the interactive biofeedback theory. Thus, for example, when bone marrow mononuclear cells are administered to a patient with a sequela of cerebral infarction, and the patient performs an appropriate physical exercise, the effect of functional recovery from the sequela of the cerebral infarction is promoted.