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    METHOD FOR PRODUCING ACTIVE GCMAF
    2.
    发明公开
    METHOD FOR PRODUCING ACTIVE GCMAF 审中-公开

    公开(公告)号：EP3725883A1

    公开(公告)日：2020-10-21

    申请号：EP18889081.8

    申请日：2018-12-14

    申请人： Foundation for Biomedical Research and Innovation at Kobe

    发明人： NABESHIMA Yo-ichi ,  NABESHIMA Yoko ,  ABE Chiaki

    IPC分类号： C12N15/12 ,  C12P21/02

    摘要： The purpose of the present invention is to provide a method for producing active GcMAF more simply and at a high yield. The present invention is a method for producing active GcMAF comprising a step for culturing host cells which are transfected with a VDBP expression vector in serum-free medium. This culture is preferably a suspension culture. In addition, this method for producing active GcMAF is also characterized by not requiring an enzyme treatment step for deglycosylation.

    PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR MILD COGNITIVE IMPAIRMENT
    3.
    发明授权
    PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR MILD COGNITIVE IMPAIRMENT 有权

    公开(公告)号：EP2862572B1

    公开(公告)日：2018-11-28

    申请号：EP13803699.1

    申请日：2013-06-14

    申请人： Foundation for Biomedical Research and Innovation at Kobe

    发明人： IHARA, Masafumi ,  MAKI, Takakuni ,  TAGUCHI, Akihiko

    IPC分类号： A61K31/4709 ,  A61K9/14 ,  A61P25/28

    CPC分类号： A61K31/4709 ,  A61K9/0019 ,  A61K9/14 ,  C07D401/12

    摘要： Provided is a prophylactic and/or therapeutic drug for mild cognitive impairment, which can improve interstitial flow in cerebral blood vessel and the like to achieve sufficient clearance of harmful proteins accumulated in the brain. The prophylactic and/or therapeutic drug includes 6-[4-(1-cyclohexyl-1H-tetrazole-5-yl)butoxy]3,4-dihydrocarbostyril or a salt thereof as an active ingredient. The prophylactic and/or therapeutic drug can improve a flow of interstitial fluid around blood vessels in a drainage pathway to excrete harmful proteins. The prophylactic and/or therapeutic drug for mild cognitive impairment may take the form of a pharmaceutical product for oral administration, a liquid pharmaceutical product for oral administration, or an injectable preparation. The prophylactic and/or therapeutic drug for mild cognitive impairment can be used for the prevention and/or treatment of cerebral amyloid angiopathy, and can also be used for improvement of Lewy body disease, Down's syndrome, or macular degeneration.

    PHYSICAL FUNCTION RECOVERY PROMOTER
    6.
    发明公开
    PHYSICAL FUNCTION RECOVERY PROMOTER 审中-公开

    公开(公告)号：EP4098266A1

    公开(公告)日：2022-12-07

    申请号：EP20912688.7

    申请日：2020-11-26

    申请人： Foundation for Biomedical Research and Innovation at Kobe

    发明人： TAGUCHI Akihiko ,  OGAWA Yuko ,  OKINAKA Yuka ,  FUKUSHIMA Masanori ,  YAMANAKA Atsuo

    IPC分类号： A61K35/28 ,  A61K35/12 ,  A61K38/18 ,  A61K45/00 ,  A61P25/00 ,  A61P43/00

    摘要： The effect of physical exercise performed on a physical function of a subject with an irreversibly reduced physical function is promoted. Bone marrow mononuclear cells, CD34-positive cells, CD133-positive cells, or stem cells are contained. The central and peripheral nerves communicate intimately with each other. When these cells are administered to a subject, and the subject performs an appropriate physical exercise, the reduced physical function can be dramatically improved. The physical exercise is, for example, physical exercise that stimulates both of brain and peripheral nerves based on the interactive biofeedback theory. Thus, for example, when bone marrow mononuclear cells are administered to a patient with a sequela of cerebral infarction, and the patient performs an appropriate physical exercise, the effect of functional recovery from the sequela of the cerebral infarction is promoted.