公开(公告)号：EP2477030A2

公开(公告)日：2012-07-18

申请号：EP10763733.2

申请日：2010-09-07

申请人： Fundación del Hospital Nacional de Parapléjicos Para la Investigación y la Integración

发明人： DE CASTRO SOUBRIET, Fernando ,  CLEMENTE LÓPEZ, Diego ,  ORTEGA MUÑOZ, María Cristina ,  ARENZANA SANAGÉRICO, Francisco Javier

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  G01N2333/50 ,  G01N2800/285 ,  G01N2800/50

摘要： Use of the FGF-2 and anosmin-1 proteins for predicting the histopathology of the lesions of a patient suffering from a central nervous system (CNS) demyelinating disease by means of the detection of the amount of said proteins in a sample of isolated biological fluid. Furthermore, the present invention relates to a method for ascertaining the histopathological characteristics of the lesions of a patient suffering from a CNS demyelinating disease and to a kit for implementing said method. Preferably, the CNS demyelinating disease is multiple sclerosis and the biological fluid is cerebrospinal fluid (CSF)..

摘要翻译： 使用FGF-2和anosmin-1蛋白质通过检测分离的生物流体样品中所述蛋白质的量来预测患有中枢神经系统（CNS）脱髓鞘病患者的病变的组织病理学 。 此外，本发明涉及确定患有CNS脱髓鞘疾病的患者的病变的组织病理学特征的方法以及用于实施所述方法的试剂盒。 优选地，CNS脱髓鞘病是多发性硬化，生物流体是脑脊髓液（CSF）。