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公开(公告)号：EP2051997A4
公开(公告)日：2009-12-02
申请号：EP07784844
申请日：2007-08-22
发明人： MACKAY CHARLES REAY
IPC分类号： C07K16/28 , A61K39/395 , A61P37/02 , C12N5/20
CPC分类号： C07K16/2896 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
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公开(公告)号：EP2061812A4
公开(公告)日：2010-06-09
申请号：EP07784845
申请日：2007-08-22
发明人： MACKAY CHARLES REAY
IPC分类号： C07K16/28 , A01K67/027 , A61K39/395 , A61P19/02 , A61P37/06 , C12N5/20 , C12N15/06 , C12N15/12 , C12N15/63 , C12N15/90
CPC分类号： C07K14/70596 , A01K67/0278 , A01K2217/072 , A01K2227/105 , A01K2267/00 , A01K2267/0368 , A61K2039/505 , A61K2039/5156 , C07K16/2896 , C07K2317/76 , C12N15/8509 , Y10S424/809
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3.发明公开TRANSGENIC NON-HUMAN MAMMAL COMPRISING A POLYNUCLEOTIDE ENCODING HUMAN OR HUMANIZED C5AR 有权与多核苷酸编码的C5aR的人或人源化的C5aR的转基因CODIERT非人哺乳动物
公开(公告)号：EP1701611A4
公开(公告)日：2008-10-22
申请号：EP04802145
申请日：2004-12-24
发明人： MACKAY CHARLES REAY
IPC分类号： C12N15/85 , A01K67/027 , A61K49/00 , C07K14/47 , C07K14/705 , C07K14/72 , C12N15/00
CPC分类号： A61K49/0008 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2227/105 , A01K2267/03 , A01K2267/0368 , C07K14/472 , C07K14/70596 , C07K14/723 , C12N15/8509 , C12N2800/30
摘要： The present invention relates to transgenic non-human mammals comprising a polynucleotide encoding a human or humanized C5aR. The invention also relates to use of the transgenic non-human mammals in methods of screening for agonists, inverse agonists and antagonists of human C5aR and for testing efficacy of C5aR agonists, inverse agonists and antagonists in various animal models of disease.
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