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12 条记录 (耗时 0.011 秒)

    MODIFIED KAPPA LIGHT CHAIN-BINDING POLYPEPTIDES
    3.
    发明公开
    MODIFIED KAPPA LIGHT CHAIN-BINDING POLYPEPTIDES 审中-公开
    修饰的KAPPA轻链结合多肽

    公开(公告)号：EP3233892A1

    公开(公告)日：2017-10-25

    申请号：EP15822920.3

    申请日：2015-12-11

    申请人： GE Healthcare BioProcess R&D AB

    发明人： RODRIGO, Gustav ,  ANDER, Mats ,  BJORKMAN, Tomas

    IPC分类号： C07K14/195

    CPC分类号： C07K14/195 ,  C07K1/22 ,  C07K16/00 ,  C07K2317/55 ,  C07K2317/569 ,  C07K2319/02

    摘要： A kappa light chain-binding polypeptide comprising or consisting essentially of one or more binding domains of Peptostreptococcus Protein L, each of said domains being selected from the group consisting of domain 2, domain 3 and domain 4.

    摘要翻译： 本发明公开了包含消化链球菌属蛋白L的突变结合结构域的κ轻链结合多肽，其中亲本域的至少一个天冬酰胺残基由SEQ ID NO：2定义或与SEQ ID NO：2具有至少95％或98％的序列同源性 -6或2已被突变为另一种不是天冬酰胺，脯氨酸或半胱氨酸的氨基酸残基。

    MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES
    7.
    发明公开
    MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES 审中-公开

    公开(公告)号：EP3221347A1

    公开(公告)日：2017-09-27

    申请号：EP15797940.2

    申请日：2015-11-16

    申请人： GE Healthcare BioProcess R&D AB

    发明人： RODRIGO, Gustav ,  BJORKMAN, Tomas ,  ANDER, Mats

    IPC分类号： C07K16/06 ,  C07K1/22

    摘要： An Fc-binding polypeptide of improved alkali stability, comprising a mutant of an Fc-binding domain of Staphylococcus Protein A (SpA), as defined by SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:22, SEQ ID NO 51 or SEQ ID NO 52 wherein at least the asparagine or serine residue at the position corresponding to position 11 in SEQ ID NO:4-7 has been mutated to an amino acid selected from the group consisting of glutamic acid, lysine, tyrosine, threonine, phenylalanine, leucine, isoleucine, tryptophan, methionine, valine, alanine, histidine and arginine.

    MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES
    8.
    发明公开
    MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES 审中-公开
    突变的免疫球蛋白结合多肽

    公开(公告)号：EP3221338A1

    公开(公告)日：2017-09-27

    申请号：EP15797942.8

    申请日：2015-11-16

    申请人： GE Healthcare BioProcess R&D AB

    发明人： RODRIGO, Gustav ,  BJORKMAN, Tomas ,  ANDER, Mats

    IPC分类号： C07K14/31 ,  B01D15/38 ,  C12N15/09

    摘要： An Fc-binding polypeptide of improved alkali stability, comprising a mutant of an Fc-binding domain of Staphylococcus Protein A (SpA), as defined by SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO 26 or SEQ ID NO 27, wherein at least the alanine residue at the position corresponding to position 42 in SEQ ID NO:4-7 has been mutated to arginine and/or wherein at least the aspartic acid residue at the position corresponding to position 37 in SEQ ID NO:4-7 has been mutated to glutamic acid.

    摘要翻译： 如SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3，SEQ ID NO：2所示的包含葡萄球菌蛋白A的Fc结合结构域的突变体（SpA）的改善的碱稳定性的Fc结合多肽 SEQ ID NO：4，SEQ ID NO：5，SEQ ID NO：6，SEQ ID NO：7，SEQ ID NO：8，SEQ ID NO：26或SEQ ID NO：27，其中至少对应于位置42的位置的丙氨酸残基 在SEQ ID NO：4-7中突变为精氨酸和/或其中在对应于SEQ ID NO：4-7中的37位的位置处至少天冬氨酸残基已经突变为谷氨酸。