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1.发明公开
公开(公告)号：EP4442280A1
公开(公告)日：2024-10-09
申请号：EP22901407.1
申请日：2022-12-01
申请人： KANAGAWA INSTITUTE OF INDUSTRIAL SCIENCE AND TECHNOLOGY , University of Tsukuba , Metagen, Inc.
发明人： Fukuda Shinji , Nakato Gaku , OBANA Nozomu , Furukawa Risako
IPC分类号： A61K45/00 , A61K39/02 , A61K39/395 , A61P37/08 , C12Q1/02 , G01N33/68 , C07K14/195
CPC分类号： A61K39/02 , A61K39/395 , A61K45/00 , A61P37/08 , C07K14/195 , C12Q1/02 , G01N33/68
摘要： The present invention addresses the problem of revealing the mechanism of allergy development in which a bacterium of the family Lachnospiraceae, which is an enteric bacterium, including Ruminococcus gnavus (R. gnavus) is involved and of developing a means for preventing or treating allergies by intervening in the mechanism. The inventors of the present invention conducted an intensive study and, as a result, found that an Ibp protein from a bacterium of the family Lachnospiraceae is involved in development of allergies and showed that the above problem can be solved. That is, it is possible to prevent allergic reactions occurring in vivo by administration or induction of in vivo production of a substance that binds to the Ibp protein from a bacterium of the family Lachnospiraceae.
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2.发明公开
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公开(公告)号：EP4409018A1
公开(公告)日：2024-08-07
申请号：EP22798004.2
申请日：2022-09-29
申请人： Conagen Inc.
IPC分类号： C12P23/00 , C07K14/195 , C12N9/02
CPC分类号： C12P23/00 , C07K14/195 , C12N9/0069 , C12N15/52 , C12R2001/64520210501 , C12R2001/0120210501 , C12Y113/11063 , C12Y101/01002 , C12Y203/0102 , C12Y203/01199 , C12N9/0006 , C12N9/1029
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公开(公告)号：EP4398736A1
公开(公告)日：2024-07-17
申请号：EP21786698.7
申请日：2021-09-09
申请人： POET Research, Inc.
发明人： MANNING, Andrew J. , BLY, Steven T.
IPC分类号： A23K10/14 , A23K10/30 , A23K10/38 , A23K20/189 , A23L5/20 , A23L7/104 , A61P31/10 , A61P39/00 , C12N9/02 , C12N15/52
CPC分类号： A23K10/30 , A23K10/38 , A23K10/14 , A23K20/189 , C12N15/52 , A61P31/10 , A61P39/00 , A23L7/104 , A23L5/25 , C12Y114/13 , C12N9/0073 , C12Y304/14002 , C12N9/485 , C12N9/1029 , C12N9/0067 , C12Y112/07002 , C12N9/0061 , C12Y110/03002 , C12Y204/01035 , C12N9/1051 , C12N9/0051 , C12Y108/98001 , C12Y111/01013 , C12N9/0065 , C12N9/248 , C12Y111/01015 , C12R2001/86520210501 , C12R2001/8420210501 , C12P7/08 , C12N9/0071 , C07K14/195 , Y02P60/87
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公开(公告)号：EP3896156B1
公开(公告)日：2024-07-17
申请号：EP18942717.2
申请日：2018-12-12
IPC分类号： C12N9/10
CPC分类号： C12N15/65 , C12P13/08 , C12N15/74 , C12N9/1022 , C12Y202/01006 , C07K14/195
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公开(公告)号：EP4380608A1
公开(公告)日：2024-06-12
申请号：EP22854119.9
申请日：2022-08-05
申请人： Yale University
发明人： VINETZ, Joseph
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公开(公告)号：EP4371997A1
公开(公告)日：2024-05-22
申请号：EP21953717.2
申请日：2021-08-18
发明人： LIU, Shaowei , XIE, Fuli , HE, Jingxiong , YUE, Feifei , LI, Qianwen
IPC分类号： C07K14/21 , C12N15/31 , C12Q1/6869 , C12N1/21 , C12N15/70
CPC分类号： C07K14/195 , C07K14/21 , C12N15/70 , C12Q1/6869 , C12N15/74
摘要： The present invention belongs to the technical field of characterization of target analyte properties, and particularly provides a mutant of a porin monomer, a protein pore comprising same, and use thereof in the detection of a target analyte, wherein an amino acid of the mutant of the porin monomer comprises a sequence set forth in SEQ ID NO: 1 or a sequence having at least 99%, 98%, 97%, 96%, 95%, 90%, 80%, 70%, 60%, or 50% identity thereto, and the amino acid of the mutant of the porin monomer comprises mutations at one or more positions corresponding to T71, S75, or F76 of SEQ ID NO: 1.
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公开(公告)号：EP4368253A1
公开(公告)日：2024-05-15
申请号：EP22206059.2
申请日：2022-11-08
申请人： Eberhard Karls Universität Tübingen, Medizinische Fakultät , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： Skokowa, Julia , ElGamacy, Mohammad
IPC分类号： A61P43/00 , C07K14/195
CPC分类号： C07K14/195 , A61P43/00 , A61K38/164
摘要： The present invention relates to a polypeptide for use as a metal-binder, a protein comprising said polypeptide, a nucleic acid molecule encoding said polypeptide or protein, an expression vector comprising the nucleic acid molecule, a recombinant host cell comprising said polypeptide, protein, nucleic acid molecule and/or expression vector, a pharmaceutical composition comprising the said polypeptide, protein, nucleic acid molecule, expression vector and/or host cell, and to a kit.
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公开(公告)号：EP4356135A1
公开(公告)日：2024-04-24
申请号：EP22735381.0
申请日：2022-06-17
IPC分类号： G01N33/543 , C07K14/00
CPC分类号： G01N33/54353 , G01N2333/24520130101 , C07K14/195 , C07K2319/0020130101 , C07K2319/2120130101
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10.发明公开
公开(公告)号：EP4353814A1
公开(公告)日：2024-04-17
申请号：EP22804720.5
申请日：2022-05-18
发明人： MIYATAKE Ryo , USHIKI Norisuke , ISAKA Koji
摘要： [Problem of invention] To provide a recombinant microorganism and a method for manufacturing a diamine that realize at least one of a simplified process and a reduction in effluent treatment cost in production of a diamine, and to provide a halophilic and/or alkalophilic recombinant microorganism having suppressed N-acetyldiamine production.
[Solution of problem] A halophilic and/or alkalophilic recombinant microorganism having a diamine producing ability, in which the diamine is represented by formula NH2CH2(CH2)nCH2NH2 (in the formula, n is an integer of 0 to 10), and the recombinant microorganism resulting from modification of a halophilic and/or alkalophilic host microorganism so as to impart a diamine producing ability; and a halophilic and/or alkalophilic recombinant microorganism having a diamine producing ability, the recombinant microorganism containing one or more genetic modifications that suppress an N-acetylation enzyme that N-acetylates a diamine compound to produce an N-acetyldiamine compound.
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