公开(公告)号：EP2075253A1

公开(公告)日：2009-07-01

申请号：EP09004418.1

申请日：2001-06-20

申请人： Genentech, Inc.

发明人： Baker, Kevin, P. ,  Ferrara, Napoleone ,  Gerber, Hanspeter ,  Gerriten, Mary, E. ,  Goddard, Audrey ,  Godowski, Paul, J. ,  Gurney, Austin, L. ,  Hillan, Kenneth, J. ,  Marsters, Scot, A. ,  Pan, James ,  Paoni, Nicholas, F. ,  Stephan, Jean-Philippe, F. ,  Watanabe, Colin, K. ,  Williams, P. Mickey ,  Wood, William, I. ,  Ye, Weilan

IPC分类号： C07K14/47 ,  C12N15/12 ,  A61K38/17 ,  C07K16/18

CPC分类号： C07K14/47

摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy.
In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 组合物和方法是游离缺失盘用于刺激血管生成抑制或和/或在cardiovascularization哺乳动物，包括人类。 药物组合物是基于多肽或拮抗剂于此thathave已经确定了一个或多个本文采用。 疾病也可诊断，预防或创伤的组合物处理包括：如伤口，各种癌症和血管包括动脉硬化和心脏肥大症。 此外，本发明涉及新的多肽和编码这些多肽的核酸分子。 因此，在提供的是载体和宿主细胞包含这些核酸序列，嵌合多肽分子包含本发明的多肽融合到结合本发明的多肽的异源多肽序列，抗体和方法用于制造本多肽 发明。