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8 条记录 (耗时 0.015 秒)

    2,5-DISUBSTITUTED-PYRIDYL NICOTINIC LIGANDS, AND METHODS OF USE THEREOF
    2.
    发明公开
    2,5-DISUBSTITUTED-PYRIDYL NICOTINIC LIGANDS, AND METHODS OF USE THEREOF 审中-公开
    2,5-二取代 - 吡啶基烟碱配体及其使用方法

    公开(公告)号：EP2776030A1

    公开(公告)日：2014-09-17

    申请号：EP12848512.5

    申请日：2012-11-09

    申请人： Georgetown University ,  Duke University

    发明人： XIAO, Yingxian ,  KELLAR, Kenneth, J. ,  BROWN, Milton, L. ,  PAIGE, Mikell, A. ,  LIU, Yong ,  LEVIN, Edward, D. ,  REZVANI, Amir, H.

    IPC分类号： A61K31/44

    CPC分类号： A61K31/4427 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/006 ,  A61K31/4439 ,  C07D401/12

    摘要： Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.

    摘要翻译： 公开了作为烟碱乙酰胆碱受体的配体的杂环化合物。 所述化合物可用于治疗患有任何一种治疗适应症的哺乳动物，所述治疗适应症包括阿尔茨海默病，帕金森病，运动障碍，图雷特综合征，精神分裂症，注意力缺陷障碍，焦虑，疼痛，抑郁症，强迫症，滥用化学物质 ，酗酒，记忆力减退，假性痴呆，甘塞综合征，偏头痛，贪食症，肥胖症，经前期综合征或晚期黄体期综合征，吸烟，创伤后综合征，社交恐怖症，慢性疲劳综合症，早泄，勃起困难，神经性厌食症， 睡眠障碍，孤独症，缄默症，拔毛癖和体温过低。

    2-HALO-5-ALKYNYL-PYRIDYL NICOTINIC LIGANDS
    5.
    发明公开
    2-HALO-5-ALKYNYL-PYRIDYL NICOTINIC LIGANDS 审中-公开
    2-卤代-5-炔基 - 吡啶基烟碱配体

    公开(公告)号：EP2983666A1

    公开(公告)日：2016-02-17

    申请号：EP14775233.1

    申请日：2014-03-26

    申请人： Georgetown University

    发明人： XIAO, Yingxian ,  KELLAR, Kenneth, J. ,  BROWN, Milton, L. ,  PAIGE, Mikell, A. ,  LIU, Yong

    IPC分类号： A61K31/44 ,  A61K31/397 ,  C07D205/02

    CPC分类号： C07D401/12

    摘要： Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.

    PHENYL-SUBSTITUTED NICOTINIC LIGANDS, AND METHODS OF USE THEREOF
    7.
    发明公开
    PHENYL-SUBSTITUTED NICOTINIC LIGANDS, AND METHODS OF USE THEREOF 审中-公开
    苯基取代的配体烟碱及其使用方法

    公开(公告)号：EP2776423A1

    公开(公告)日：2014-09-17

    申请号：EP12847869.0

    申请日：2012-11-09

    申请人： Georgetown University ,  Duke University

    发明人： BROWN, Milton, L. ,  PAIGE, Mikell, A. ,  XIAO, Yingxian ,  KELLAR, Kenneth, J. ,  YENUGONDA, Venkata, Mahidhar ,  LEVIN, Edward, D. ,  REZVANI, Amir, H.

    IPC分类号： C07D403/06

    CPC分类号： C07D401/12 ,  C07D213/65

    摘要： Disclosed are compounds and methods of using them to treat a disorder selected from the group consisting of addiction, pain, obesity, schizophrenia, epilepsy, mania and manic depression, anxiety, Alzheimer's disease, learning deficit, cognition deficit, attention deficit, memory loss, Lewy Body Dementia, Attention Deficit Hyperactivity Disorder (ADHD), Parkinson's disease, Huntington's disease, Tourette's syndrome, amyotrophic lateral sclerosis, inflammation, stroke, spinal cord injury, dyskinesias, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, autism, mutism, trichotillomania, hypothermia, and disorders of sleep.