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1.发明公开NOVEL 4-(AZACYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS 有权NEW 4-（氮杂环烷基）苯-1,3-二醇化合物的合适的酪氨酸酶，PROCESS FOR PRODUCING及其用途在人类医学和化妆品中
公开(公告)号：EP2373620A1
公开(公告)日：2011-10-12
申请号：EP09763959.5
申请日：2009-12-02
IPC分类号： C07D211/22 , C07D205/02 , C07D207/22 , C07D401/04 , C07D295/185 , A61K31/445 , A61P17/00
CPC分类号： C07D401/12 , A61K9/06 , C07D205/04 , C07D207/08 , C07D207/16 , C07D211/22 , C07D211/26 , C07D211/60
摘要： The present invention relates to novel 4- (azacycloalkyl) benzene-1, 3-diol compounds corresponding to general formula (I) below: Formula (I) to the compositions containing same, to the process for the preparation thereof and to the use thereof in pharmaceutical or cosmetic compositions for use in the treatment or prevention of pigmentary disorders.
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公开(公告)号：EP2010227A2
公开(公告)日：2009-01-07
申请号：EP07734363.0
申请日：2007-04-20
IPC分类号： A61K51/08 , C07B59/00 , C07C213/08 , C07C215/14 , C07C331/28 , C07D205/02 , C07K7/08
CPC分类号： A61K51/087 , A61K51/088 , C07B59/008 , C07C215/08 , C07C215/14 , C07C271/28 , C07C331/28 , C07D205/04 , C07K1/13 , C07K14/47
摘要： The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in particular 18F-labelled prosthetic groups for use in the preparation as well as non-labelled intermediates useful in the preparation of the [18F]-labelled prosthetic groups. [18F]-labelled compounds useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET) are also provided.
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3.发明授权NAPHTHOPYRAN DERIVATIVES, COMPOSITIONS AND (CO)POLYMER MATRICES CONTAINING THE SAME 失效NAPHTHOPYRANDERIVATE，制剂和含有SAMe（CO）聚合物基质
公开(公告)号：EP0984929B1
公开(公告)日：2002-09-11
申请号：EP98911739.5
申请日：1998-03-17
申请人： Corning S.A.
发明人： BREYNE, Olivier , CHAN, You-Ping
IPC分类号： C07D205/02 , C07D207/02 , C07D223/04 , C07D225/02 , C07D311/92 , C07D313/18 , C07D333/02 , C07D337/04 , C07D337/16 , C07D409/10 , C08K5/15 , G02B5/23
CPC分类号： C08F24/00 , C03C1/10 , C03C4/06 , C03C14/008 , C03C2214/17 , C07D311/92 , C09K9/02
摘要： For subject, the present invention has novel naphthopyran derivatives of formula (I) optionally substituted in position(s) 2, 3, 4, 6, 7, 8, 9 or/and 10; the substituent Z in position 5 being of formula -C(R1)(R2)(OR3). The invention also relates to compositions and (co)polymer matrices containing such derivatives. Said derivatives have interesting photochromic properties.
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4.发明公开NAPHTHOPYRAN DERIVATIVES, COMPOSITIONS AND (CO)POLYMERS MATRICES CONTAINING SAME 失效NAPHTHOPYRANDERIVATE，制剂和含（共）聚合物基质
公开(公告)号：EP0984929A1
公开(公告)日：2000-03-15
申请号：EP98911739.5
申请日：1998-03-17
申请人： CORNING INCORPORATED
发明人： BREYNE, Olivier , CHAN, You-Ping
IPC分类号： C07D205/02 , C07D207/02 , C07D223/04 , C07D225/02 , C07D311/92 , C07D313/18 , C07D333/02 , C07D337/04 , C07D337/16 , C07D409/10 , C08K5/15 , G02B5/23
CPC分类号： C08F24/00 , C03C1/10 , C03C4/06 , C03C14/008 , C03C2214/17 , C07D311/92 , C09K9/02
摘要： For subject, the present invention has novel naphthopyran derivatives of formula (I) optionally substituted in position(s) 2, 3, 4, 6, 7, 8, 9 or/and 10; the substituent Z in position 5 being of formula -C(R1)(R2)(OR3). The invention also relates to compositions and (co)polymer matrices containing such derivatives. Said derivatives have interesting photochromic properties.
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公开(公告)号：EP2983666B1
公开(公告)日：2019-10-09
申请号：EP14775233.1
申请日：2014-03-26
IPC分类号： A61K31/44 , A61K31/397 , C07D205/02 , A61P25/00
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公开(公告)号：EP3080086B1
公开(公告)日：2017-07-05
申请号：EP14809812.2
申请日：2014-12-04
申请人： Unilever PLC, a company registered in England and Wales under company no. 41424 of , UNILEVER N.V.
IPC分类号： C07D215/08 , C07D217/06 , C07C231/02 , C07D205/02 , C07D207/06 , C07D211/16 , C07D211/62 , C07D295/185
CPC分类号： C07D211/16 , C07C231/02 , C07C2603/74 , C07D205/02 , C07D207/06 , C07D211/62 , C07D215/08 , C07D217/06 , C07D295/185 , C07C233/58
摘要： An effective process of making adamantanamide, which process is fast, does not the use of organic solvents or labor-intensive isolation or purification of the product, by removal of organic solvent or by-products, and has improved yield and purity.
摘要翻译： 制备金刚烷胺的有效方法是快速的，不使用有机溶剂或劳动密集型分离或纯化产物，除去有机溶剂或副产物，并且具有提高的收率和纯度。
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公开(公告)号：EP2983666A1
公开(公告)日：2016-02-17
申请号：EP14775233.1
申请日：2014-03-26
IPC分类号： A61K31/44 , A61K31/397 , C07D205/02
CPC分类号： C07D401/12
摘要： Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.
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8.发明公开NOVEL BICYCLIC HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM 审中-公开新的双环杂环化合物，工艺用于生产成分和
公开(公告)号：EP1814885A4
公开(公告)日：2009-12-16
申请号：EP05857024
申请日：2005-11-23
申请人： REDDY US THERAPEUTICS INC , PAL MANOJIT , RAO YELESWARAPU KOTESWAR , KHANNA ISH KUMAR , SWAMY NALIVELA KUMARA , SUBRAMANIAN VENKATARAMAN , BATCHU VENKATESWARA RAO , IQBAL JAVED , PILLARISETTI SIVARAM
发明人： REDDY US THERAPEUTICS INC , PAL MANOJIT , RAO YELESWARAPU KOTESWAR , KHANNA ISH KUMAR , SWAMY NALIVELA KUMARA , SUBRAMANIAN VENKATARAMAN , BATCHU VENKATESWARA RAO , IQBAL JAVED , PILLARISETTI SIVARAM
IPC分类号： C07D487/04 , A61K31/221 , A61K31/415 , A61K31/437 , A61K31/519 , A61K31/5365 , C07D205/02 , C07D231/04 , C07D231/10 , C07D471/04
CPC分类号： C07D471/04 , C07D487/04
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9.发明公开NOVEL BICYCLIC HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM 审中-公开新的双环杂环化合物，工艺用于生产成分和
公开(公告)号：EP1814885A2
公开(公告)日：2007-08-08
申请号：EP05857024.3
申请日：2005-11-23
申请人： Reddy US Therapeutics, Inc. , Pal, Manojit , Rao, Yeleswarapu Koteswar , Khanna, Ish Kumar , Swamy, Nalivela, Kumara , Subramanian, Venkataraman , Batchu, Venkateswara Rao , Iqbal, Javed , Pillarisetti, Sivaram
发明人： Reddy US Therapeutics, Inc. , Pal, Manojit , Rao, Yeleswarapu Koteswar , Khanna, Ish Kumar , Swamy, Nalivela, Kumara , Subramanian, Venkataraman , Batchu, Venkateswara Rao , Iqbal, Javed , Pillarisetti, Sivaram
IPC分类号： C07D487/04 , C07D471/04 , A61K31/519 , A61K31/5365 , C07D231/04 , C07D231/10 , C07D205/02 , A61K31/415 , A61K31/437 , A61K31/221
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.
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公开(公告)号：EP2419404A1
公开(公告)日：2012-02-22
申请号：EP10714787.8
申请日：2010-04-14
申请人： Abbott Laboratories
发明人： DEGOEY, David, A. , HUTCHINS, Charles, W. , KATI, Warren, M. , DONNER, Pamela, L. , NELSON, Lissa, T. , JINKERSON, Tammie, K. , KEDDY, Ryan, G. , MOTTER, Christopher, E. , MATULENKO, Mark, A. , KRUEGER, Allan, C. , PATEL, Sachin, V. , RANDOLPH, John, T. , SOLTWEDEL, Todd, N.
IPC分类号： C07D205/02 , C07D207/16 , C07D209/52 , C07D401/12 , C07D403/04 , C07D403/12 , C07D413/12 , C07D417/12 , A61K31/454 , A61P29/00
CPC分类号： C07D207/16 , A61K31/4025 , A61K31/4184 , A61K31/454 , A61K31/5377 , A61K38/00 , C07D205/04 , C07D207/22 , C07D209/52 , C07D211/60 , C07D263/06 , C07D277/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07K5/06034 , C07K5/06043 , C07K5/0606 , C07K5/06069 , C07K5/06078 , C07K5/06139
摘要： Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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