公开(公告)号：EP3134149A1

公开(公告)日：2017-03-01

申请号：EP15783359.1

申请日：2015-04-24

申请人： Georgia Tech Research Corporation

发明人： MCALLISTER, Devin ,  PRAUSNITZ, Mark ,  HENRY, Sebastien ,  GUO, Xin Dong

IPC分类号： A61M5/158

CPC分类号： A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053

摘要： A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.

摘要翻译： 提供微针阵列用于将药物或其它物质施用到生物组织中。 阵列包括基底; 从所述基底基板的一侧延伸的第一漏斗部分; 和两个或多个从第一漏斗部分延伸的固体微针，其中两个或更多个微针包含感兴趣的物质。 还提供了制作微针阵列的方法。 该方法可以包括提供具有两个或更多个空腔的无孔和透气模具，每个腔限定微针; 用包括感兴趣的物质和液体载体的流体材料填充空腔; 干燥流体材料以除去液体载体的至少一部分并形成包括感兴趣物质的多个微针，其中填充物在施加在模具的相对表面之间的压力差下进行。