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公开(公告)号：EP4098313A1
公开(公告)日：2022-12-07
申请号：EP22186878.9
申请日：2014-09-30
IPC分类号： A61M37/00
摘要： A microneedle patch for administration of a substance of interest into a biological tissue, the microneedle patch comprising: a base substrate having a microneedle side and an opposing back side; solid microneedles extending from the microneedle side of the base substrate, the solid microneedles being formed of a composition which comprises (i) a substance of interest selected from active pharmaceutical ingredients, allergens, vitamins, cosmetic agents, cosmeceuticals, and markers, and (ii) a matrix material in which the substance of interest is dispersed; and an indicator connected to the opposing back side of the base substrate, wherein the indicator is configured to provide an audible, tactile, and visual signal when a force applied to the patch by a user, in the course of applying the patch to a biological tissue to insert the solid microneedles into the biological tissue, meets or exceeds a predetermined threshold.
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2.发明公开MICRONEEDLES AND METHODS OF MANUFACTURE THEREOF 审中-公开MIKRONADELN UND VERFAHREN ZUR HERSTELLUNG DAVON
公开(公告)号：EP3134149A1
公开(公告)日：2017-03-01
申请号：EP15783359.1
申请日：2015-04-24
IPC分类号： A61M5/158
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053
摘要： A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.
摘要翻译： 提供微针阵列用于将药物或其它物质施用到生物组织中。 阵列包括基底; 从所述基底基板的一侧延伸的第一漏斗部分; 和两个或多个从第一漏斗部分延伸的固体微针，其中两个或更多个微针包含感兴趣的物质。 还提供了制作微针阵列的方法。 该方法可以包括提供具有两个或更多个空腔的无孔和透气模具，每个腔限定微针; 用包括感兴趣的物质和液体载体的流体材料填充空腔; 干燥流体材料以除去液体载体的至少一部分并形成包括感兴趣物质的多个微针，其中填充物在施加在模具的相对表面之间的压力差下进行。
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公开(公告)号：EP3041504A1
公开(公告)日：2016-07-13
申请号：EP14843082.0
申请日：2014-09-03
发明人： MISTILIS, Matthew Joseph , EDENS, William Christopher , BOMMARIUS, Andreas Sebastian , PRAUSNITZ, Mark
IPC分类号： A61K39/12 , A61K39/145 , A61K39/165 , C12N7/01
CPC分类号： A61K9/0021 , A61K39/12 , A61K39/145 , A61K39/165 , A61K2039/5256 , A61K2039/70 , C12N7/00 , C12N2760/16134 , C12N2760/16234 , C12N2760/16334 , C12N2760/18434
摘要： Formulations and methods are provided for stabilizing antigens in dry solid vaccines. One aspect relates to dry solid formulations of influenza vaccines including one or more excipients identified as imparting stability to influenza antigens. Another aspect relates to dry solid formulations of measles vaccines including one or more excipients identified as imparting stability to a measles antigen. The formulations may be in a form suitable for reconstitution in a physiologically acceptable liquid vehicle to form an injectable solution or suspension for administration to a patient or in the form of dissolvable microneedles or coated microneedles.
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4.发明公开
公开(公告)号：EP3423040A1
公开(公告)日：2019-01-09
申请号：EP17760704.1
申请日：2017-03-01
发明人： TADROS, Andrew , PRAUSNITZ, Mark
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公开(公告)号：EP3052181A1
公开(公告)日：2016-08-10
申请号：EP14848387.8
申请日：2014-09-30
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/586
摘要： Embodiments of the present application provide microneedle patches and systems, and methods for use of such patches and systems. In one aspect, a microneedle patch is provided including a tab portion for handling the microneedle patch. In another aspect, a system is provided including a microneedle patch and a tray for housing the microneedle patch. In still another aspect, various indicators providing for providing feedback prior to, during, and after administration of the microneedle patch are provided. Advantageously, the described microneedle patches and systems provide improved handling and ease of application of the microneedle patches to skin for the delivery of therapeutic agents.
摘要翻译： 本发明的实施例提供微针贴片和系统，以及使用这种贴片和系统的方法。 一方面，提供了一种微针贴片，其包括用于处理微针贴片的突片部分。 在另一方面，提供一种包括微针补片和用于容纳微针补片的托盘的系统。 另一方面，提供了在施加微针补片之前，期间和之后提供反馈的各种指标。 有利地，所描述的微针贴片和系统提供改善的处理和将微针贴片施用于皮肤以便递送治疗剂的易用性。
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