公开(公告)号：EP2525779A4

公开(公告)日：2014-07-09

申请号：EP11734855

申请日：2011-01-18

申请人： HANMI SCIENCE CO LTD

发明人： BAE SUNG MIN ,  IM DAE SEONG ,  KIM MIN YOUNG ,  LIM CHANG KI ,  JUNG SUNG YOUB ,  KWON SE CHANG

IPC分类号： A61K9/08 ,  A61K9/22 ,  A61K38/16 ,  A61P7/06

CPC分类号： A61K47/02 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/183 ,  A61K47/26 ,  A61K47/6811 ,  A61K47/6835

摘要： Disclosed is a liquid formulation which allows long-acting EPO conjugates, that have improved in vivo duration and stability, to be stable when stored for a long period of time. It comprises a stabilizer composition characterized by buffer and mannitol. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting EPO conjugates.

公开(公告)号：EP2552474A4

公开(公告)日：2014-02-26

申请号：EP11763093

申请日：2011-04-04

申请人： HANMI SCIENCE CO LTD

发明人： SONG DAE HAE ,  SHIN JAE HEE ,  PARK YOUNG JIN ,  IM DAE SEONG ,  BAE SUNG MIN ,  KWON SE CHANG

IPC分类号： A61K38/28 ,  A61K9/20 ,  A61K47/34 ,  A61K47/40

CPC分类号： A61K38/28 ,  A61K47/68 ,  A61K47/6883 ,  C07K14/62 ,  C07K2319/30

公开(公告)号：EP2593084A4

公开(公告)日：2014-11-05

申请号：EP11807064

申请日：2011-07-14

申请人： HANMI SCIENCE CO LTD

发明人： HONG SUNG HEE ,  LEE BYUNG SUN ,  IM DAE SEONG ,  LEE JAE MIN ,  BAE SUNG MIN ,  KWON SE CHANG

IPC分类号： A61K9/08 ,  A61K38/27 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61K47/48

CPC分类号： A61K47/48415 ,  A61K9/0019 ,  A61K9/08 ,  A61K38/27 ,  A61K47/12 ,  A61K47/26 ,  A61K47/60 ,  A61K47/68 ,  C07K2319/30

摘要： Disclosed is a liquid formulation of long-acting human growth hormone (hGH) conjugate, free of albumin, which can guarantee the stability of the long-acting hGH conjugate when stored over a long period of time, wherein the long-acting human growth hormone conjugate includes a human growth hormone linked to an immunoglobulin Fc region, and has a prolonged in vivo stability compared to the native form. The liquid formulation of hGH conjugate including a pH 5.0˜6.0 buffer, a sugar alcohol, a salt and a non-ionic surfactant is free of human serum albumin and other hazardous factors which are potentially contaminated with viruses, and can provide excellent storage stability customized for a long-acting hGH conjugate composed of an hGH polypeptide and an immunoglobulin Fc region which has higher molecular weight and in vivo durability, compared to the native.

公开(公告)号：EP2632433A4

公开(公告)日：2014-04-16

申请号：EP11836617

申请日：2011-10-26

申请人： HANMI SCIENCE CO LTD

发明人： IM DAE SEONG ,  LEE JAE MIN ,  LEE JONG SOO ,  BAE SUNG MIN ,  KWON SE CHANG

IPC分类号： A61K9/08 ,  A61K38/21 ,  A61K47/36 ,  A61P31/12

CPC分类号： A61K47/48415 ,  A61K9/0019 ,  A61K38/212 ,  A61K47/26 ,  A61K47/68 ,  A61K47/6813 ,  C07K14/56 ,  C07K16/46 ,  C07K2319/30