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1.发明授权SUBCUTANEOUS IMPLANTS CONTAINING A DEGRADATION-RESISTANT POLYLACTIDE POLYMER AND A LH-RH ANALOGUE 有权亚科植入物麻醉剂EINEM GEGEN ABBAU聚电解质聚合物在EINEM LH-RH-ANALOGON
公开(公告)号：EP2012746B1
公开(公告)日：2017-02-22
申请号：EP07723412.8
申请日：2007-03-20
申请人： Hexal AG
CPC分类号： A61K9/0024 , A61K9/204
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2.发明公开NICHT-AUSSPUCKBARER, ORALER, SCHNELL-ZERFALLENDER FILM FÜR EIN NEUROLEPTIKUM 有权NON-AUSSPUCKBARER，口服快速降低WATCHING FILM奥氮平含
公开(公告)号：EP1904029A2
公开(公告)日：2008-04-02
申请号：EP06776333.4
申请日：2006-07-20
申请人： HEXAL AG
IPC分类号： A61K9/00 , A61K9/70 , A61K31/551 , A61P25/18
CPC分类号： A61K9/006 , A61K9/0056 , A61K9/7007 , A61K31/551 , A61K31/5513
摘要： The invention relates to a film-shaped, single-layered and cavity-free preparation that does not contain any surfactants nor effervescent additives and flavor masking agents, comprised of film forming agents, one or more gelling agents and of one or more active substances selected from the group of neuroleptic drugs.
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3.发明授权NICHT-AUSSPUCKBARER, ORALER, SCHNELL-ZERFALLENDER FILM ENTHALTEND OLANZAPIN 有权NON-AUSSPUCKBARER，口服快速降低WATCHING FILM奥氮平含
公开(公告)号：EP1904029B1
公开(公告)日：2011-01-26
申请号：EP06776333.4
申请日：2006-07-20
申请人： Hexal AG
IPC分类号： A61K9/00 , A61K9/70 , A61K31/551 , A61P25/18
CPC分类号： A61K9/006 , A61K9/0056 , A61K9/7007 , A61K31/551 , A61K31/5513
摘要： The invention relates to a film-shaped, single-layered and cavity-free preparation that does not contain any surfactants nor effervescent additives and flavor masking agents, comprised of film forming agents, one or more gelling agents and of one or more active substances selected from the group of neuroleptic drugs.
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4.发明公开NICHT-AUSSPUCKBARER, ORALER, SCHNELL-ZERFALLENDER FILM FÜR ANTIEMETIKUM ODER ANTIMIGRÄNEMITTEL 审中-公开NON-AUSSPUCKBARER，口服快速降低观赏膜止吐药或抗偏头痛药
公开(公告)号：EP1906917A2
公开(公告)日：2008-04-09
申请号：EP06776332.6
申请日：2006-07-20
申请人： HEXAL AG
IPC分类号： A61K9/00 , A61K9/70 , A61K31/404 , A61P1/08 , A61P25/06
CPC分类号： A61K9/0056 , A61K9/7007 , A61K31/404
摘要： The invention relates to a film-shaped, single-layered and cavity-free preparation that does not contain any surfactants nor effervescent additives and flavor masking agents, comprised of film forming agents, one or more gelling agents and of one or more active substances selected from the group of antiemetics and antimigraine agents.
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公开(公告)号：EP1301179A2
公开(公告)日：2003-04-16
申请号：EP01951670.7
申请日：2001-07-12
申请人： HEXAL AG
CPC分类号： A61K9/7053 , A61K9/7061 , A61K47/02
摘要： The invention relates to a transdermal therapeutic system comprising a surface layer which is impervious with respect to an active ingredient; a self-adherent matrix layer or a plurality of matrix layers, wherein the exposed matrix layer is, at least self-adherent when the system is applied. Said system also comprises a pull-off protective coating, whereby the matrix layer(s) contains(s) one or more active ingredients and/or one or more biologically active substances and highly dispersed silicon dioxide. Said system contains silicon dioxide in order to increase skin permeation.
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6.发明授权NICHT-AUSSPUCKBARER, ORALER, SCHNELL-ZERFALLENDER FILM ENTHALTEND OLANZAPIN 有权NON-AUSSPUCKBARER，口服快速降低WATCHING FILM奥氮平含
公开(公告)号：EP1904029B2
公开(公告)日：2014-11-12
申请号：EP06776333.4
申请日：2006-07-20
申请人： Hexal AG
IPC分类号： A61K9/00 , A61K9/70 , A61K31/551 , A61P25/18
CPC分类号： A61K9/006 , A61K9/0056 , A61K9/7007 , A61K31/551 , A61K31/5513
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7.发明公开SUBCUTANEOUS IMPLANTS CONTAINING A DEGRADATION-RESISTANT POLYLACTIDE POLYMER AND A LH-RH ANALOGUE 有权与采矿对耐聚乳酸聚合物和LHRH类似物的皮下植入物
公开(公告)号：EP2012746A2
公开(公告)日：2009-01-14
申请号：EP07723412.8
申请日：2007-03-20
申请人： HEXAL AG
CPC分类号： A61K9/0024 , A61K9/204
摘要： The present invention refers to compositions comprising a LH-RH-analogue and/or pharmaceutically acceptable salts thereof in a low-dose and a degradation-resistant polylactide suitable for the preparation of subcutaneous implants. Sterilisation of the polylactide via gamma-radiation as well as temperature stress result in a negligible decomposition of less than 1000 Dalton.
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公开(公告)号：EP1301179B1
公开(公告)日：2007-07-11
申请号：EP01951670.7
申请日：2001-07-12
申请人： HEXAL AG
CPC分类号： A61K9/7053 , A61K9/7061 , A61K47/02
摘要： The invention relates to a transdermal therapeutic system comprising a surface layer which is impervious with respect to an active ingredient; a self-adherent matrix layer or a plurality of matrix layers, wherein the exposed matrix layer is, at least self-adherent when the system is applied. Said system also comprises a pull-off protective coating, whereby the matrix layer(s) contains(s) one or more active ingredients and/or one or more biologically active substances and highly dispersed silicon dioxide. Said system contains silicon dioxide in order to increase skin permeation.
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9.发明授权MATRIXKONTROLLIERTES TRANSDERMALES SYSTEM FÜR STABILE DERIVATE DER ACE-HEMMER 有权MATRIX控制型透皮SYSTEM FOR ACE抑制剂稳定衍生物
公开(公告)号：EP1299091B1
公开(公告)日：2006-10-11
申请号：EP01960496.6
申请日：2001-07-12
申请人： HEXAL AG
CPC分类号： A61K9/703 , A61K9/7061 , A61K38/556
摘要： The invention relates to a matrix controlled transdermal therapeutic system comprising, (i) a top layer which is impervious to active ingredients, (ii) a self adhesive matrix layer or several matrix layers, whereby at least the exposed matrix layer is self adhesive when the system is applied, or comprising one or several matrix layers whose surface faces away from the top layer and is provided for adhesion to the place of application, said surface being covered with an adhesive. The matrix layers contain at least one ACE inhibitor (angiotensin converting enzyme inhibitor). The metabolite thereof is a dicarboxylic acid selected from the following group: diesters, a di-salt which is obtainable with one or several bases and a mono-salt which is obtainable with one or several acids and (iii) a tear-off protective layer.
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10.发明公开MATRIXKONTROLLIERTES TRANSDERMALES SYSTEM FÜR STABILE DERIVATE DER ACE-HEMMER 有权MATRIX控制型透皮SYSTEM FOR ACE抑制剂稳定衍生物
公开(公告)号：EP1299091A2
公开(公告)日：2003-04-09
申请号：EP01960496.6
申请日：2001-07-12
申请人： HEXAL AG
CPC分类号： A61K9/703 , A61K9/7061 , A61K38/556
摘要： The invention relates to a matrix controlled transdermal therapeutic system comprising, (i) a top layer which is impervious to active ingredients, (ii) a self adhesive matrix layer or several matrix layers, whereby at least the exposed matrix layer is self adhesive when the system is applied, or comprising one or several matrix layers whose surface faces away from the top layer and is provided for adhesion to the place of application, said surface being covered with an adhesive. The matrix layers contain at least one ACE inhibitor (angiotensin converting enzyme inhibitor). The metabolite thereof is a dicarboxylic acid selected from the following group: diesters, a di-salt which is obtainable with one or several bases and a mono-salt which is obtainable with one or several acids and (iii) a tear-off protective layer.
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