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1.发明授权A PROCESS FOR PREPARING PYRIDINYLMETHYL-1H- BENZIMIDAZOLE COMPOUNDS IN ENANTIOMERICALLY ENRICHED FORM OR AS SINGLE ENANTIOMERS 无效用于生产中对映体富集形式或吡啶基甲基-1H-苯并咪唑化合物作为单一对映体
公开(公告)号：EP1740571B1
公开(公告)日：2009-07-29
申请号：EP04729974.8
申请日：2004-04-28
申请人： Hetero Drugs Limited
发明人： PARTHASARADHI REDDY, B., Hetero House , RATHNAKAR REDDY, K., Hetero Drugs Limited (R & D) , RAJI REDDY, Rapolu, Hetero Drugs Limited (R & D) , MURALIDHARA REDDY, D., Hetero Drugs Limited (R&D)
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： The present invention relates to a process for preparing substituted sulfoxides either as a single enantiomer or in an enantiomerically enriched form. Thus, racemic omeprazole is reacted with (S)-camphorsulfonyl chloride to form a diastereomeric mixture and the diastereomers are separated by fractional crystallization, followed by deprotection to give esomeprazole.
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公开(公告)号：EP1687287A1
公开(公告)日：2006-08-09
申请号：EP03773997.6
申请日：2003-11-24
申请人： Hetero Drugs Limited
发明人： PARTHASARADHI REDDY, B., Hetero House , RATHNAKAR REDDY, K., Hetero Drugs Limited (R & D) , RAJI REDDY, R., Hetero Drugs Limited (R & D) , MURALIDHARA REDDY, D., Hetero Drugs Limited (R&D) , SUBASH CHANDER REDDY, K., Hetero Drugs Ltd. (R&D)
IPC分类号： C07D291/04
CPC分类号： C07D205/08 , C07D263/22 , C07D263/26 , C07D277/34 , C07D277/36
摘要： The invention provides a process for preparing intermediate of ezetimibe, which shows hypocholesterolemic activity. Thus 3-[5-(4-fluorophenyl)-1,5-dioxopentyl]-4-phenyl-2-oxazolidinone is reduced with (-)-DIP chloride to obtain 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-2-oxazolidinone.
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3.发明公开A PROCESS FOR PREPARING PYRIDINYLMETHYL-1H- BENZIMIDAZOLE COMPOUNDS IN ENANTIOMERICALLY ENRICHED FORM OR AS SINGLE ENANTIOMERS 无效用于生产中对映体富集形式或吡啶基甲基-1H-苯并咪唑化合物作为单一对映体
公开(公告)号：EP1740571A1
公开(公告)日：2007-01-10
申请号：EP04729974.8
申请日：2004-04-28
申请人： Hetero Drugs Limited
发明人： PARTHASARADHI REDDY, B., Hetero House , RATHNAKAR REDDY, K., Hetero Drugs Limited (R & D) , RAJI REDDY, Rapolu, Hetero Drugs Limited (R & D) , MURALIDHARA REDDY, D., Hetero Drugs Limited (R&D)
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： The present invention relates to a process for preparing substituted sulfoxides either as a single enantiomer or in an enantiomerically enriched form. Thus, racemic omeprazole is reacted with (S)-camphorsulfonyl chloride to form a diastereomeric mixture and the diastereomers are separated by fractional crystallization, followed by deprotection to give esomeprazole.
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